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During the mixing of a drug with an excipient the standard deviation of the compositions of 100 mg samples tends to a constant value of

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During the mixing of a drug with an excipient the standard deviation of the compositions of 100 mg samples tends to a constant value of 0.005. The size distributions of drug (D) and excipient (E) are given in Table 1. The mean proportion by mass of drug is known to be 0.2. The densities of drug and excipient are 1100 and 900 kg/m, respectively. Determine whether the mixing is satisfactory if the criterion is a random mixture. [25] Table 1 Size distributions of drug and excipient Size x (um) 420 355 250 190 Fp(x) 1.00 0.991 0.982 0.973 FE(X) 1.00 1.00 0.977 0.967 75 53 0 150 0.964 0.946 0.746 0.654 0.047 0.284 0 0

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