Economics Task Review and critically evaluate an economic evaluation conducted alongside a trial by answering a series of questions Description Review the following paper on the cost utility of chemotherapy in patients with nonprogressive metastatic esophageal squamous cell carcinoma Part 1 15 marks Critically evaluate the economic analysis by addressing each of the following questions with justifications for your answers (a simply yes no is not sufficient) What perspective(s) is are adopted Is this appropriate Are any relevant perspectives not included What intervention alternatives are compared Is this appropriate Are any relevant alternatives not included Which costs are included Is this appropriate Are any relevant costs not included Are the costs measured and valued appropriately What evidence is the effectiveness based on What was the primary outcome of the clinical study How does this compare with the outcome used in the economic evaluation The economic evaluation is a cost utility analysis Is a cost utility analysis the appropriate type of economic evaluation How were utilities derived Is this appropriate What is the time horizon of the study Is this appropriate Was discounting applied to costs and benefits Is this appropriate What are the results of the economic evaluation How is uncertainty dealt with in the economic evaluation Is this appropriate Are any relevant analyses not included Do the authors discuss the generalisability of the results, compare the current economic evaluation with previous similar analyses, discuss the limitations of the economic evaluation and make sensible conclusions Do you find the economic evaluation useful Is it a well conducted and well reported analysis Do you have any concerns about the economic evaluation

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Economics Task Review and critically evaluate an economic evaluation conducted alongside a trial by answering a series of questions. Description Review the following paper on

Economics

Task

Review and critically evaluate an economic evaluation conducted alongside a trial by answering a series of questions.

Description

Review the following paper on the cost-utility of chemotherapy in patients with nonprogressive metastatic esophageal squamous cell carcinoma

Part 1 [15 marks]

Critically evaluate the economic analysis by addressing each of the following questions with justifications for your answers (a simply yes/no is not sufficient):

What perspective(s) is/are adopted? Is this appropriate? Are any relevant perspectives not included?
What intervention alternatives are compared? Is this appropriate? Are any relevant alternatives not included?
Which costs are included? Is this appropriate? Are any relevant costs not included? Are the costs measured and valued appropriately?
What evidence is the effectiveness based on? What was the primary outcome of the clinical study? How does this compare with the outcome used in the economic evaluation?
The economic evaluation is a cost-utility analysis. Is a cost-utility analysis the appropriate type of economic evaluation? How were utilities derived? Is this appropriate?
What is the time horizon of the study? Is this appropriate? Was discounting applied to costs and benefits? Is this appropriate?
What are the results of the economic evaluation?
How is uncertainty dealt with in the economic evaluation? Is this appropriate? Are any relevant analyses not included?
Do the authors discuss the generalisability of the results, compare the current economic evaluation with previous similar analyses, discuss the limitations of the economic evaluation and make sensible conclusions?

Do you find the economic evaluation useful? Is it a well-conducted and well-reported analysis? Do you have any concerns about the economic evaluation?