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$`efficacy$sex:efficacy$Treatment` diff lwr upr p adj male:drug_high-female:drug_high -7.803334 -10.9204503 -4.6862167 0.0000000 female:drug_low-female:drug_high -2.837133 -5.8917012 0.2174351 0.0859850 male:drug_low-female:drug_high -4.640395 -7.8671351 -1.4136552 0.0006365 female:placebo-female:drug_high 7.478145 4.3969218 10.5593689

$`efficacy$sex:efficacy$Treatment` diff lwr upr p adj male:drug_high-female:drug_high -7.803334 -10.9204503 -4.6862167 0.0000000 female:drug_low-female:drug_high -2.837133 -5.8917012 0.2174351 0.0859850 male:drug_low-female:drug_high -4.640395 -7.8671351 -1.4136552 0.0006365 female:placebo-female:drug_high 7.478145 4.3969218 10.5593689 0.0000000 male:placebo-female:drug_high 5.723143 2.5329761 8.9133095 0.0000059 female:drug_low-male:drug_high 4.966200 1.9436091 7.9887918 0.0000480 male:drug_low-male:drug_high 3.162938 -0.0335476 6.3594243 0.0543326 female:placebo-male:drug_high 15.281479 12.2319527 18.3310051 0.0000000 male:placebo-male:drug_high 13.526476 10.3669138 16.6860388 0.0000000 male:drug_low-female:drug_low -1.803262 -4.9387831 1.3322589 0.5694223 female:placebo-female:drug_low 10.315278 7.3297166 13.3008403 0.0000000 male:placebo-female:drug_low 8.560276 5.4624049 11.6581468 0.0000000 female:placebo-male:drug_low 12.118541 8.9570466 15.2800344 0.0000000 male:placebo-male:drug_low 10.363538 7.0957759 13.6313000 0.0000000 male:placebo-female:placebo -1.755003 -4.8791595 1.3691544 0.5948392

1) Does the low does of drug reduce antibody levels in males?

2) Does high does of drugs affect antibody levels in males?

3) Does the low does of drug reduce antibody levels in Females?

4) Does high does of drugs affect antibody levels in Females?

5) Does the placebo reduce antibody levels more in males than in females?

6) Does the low dose of the drug reduce antibody levels more in male than females?

7) Does the high dose of the drug reduce antibody levels more in male than females?

All are yes or no answers. Please provide explanation!

Thank you!

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