El Sayed et al BMC Nursing (2023) 22 271 https doi org 10 1186 s12912 023 01443 1 RESEARCH BMC Nursing Open Access Efficacy of acceptance and commitment therapy on impulsivity and suicidality among clients with bipolar disorders a randomized control trial Mona Metwally El Sayed', Eman Sameh Abd Elhay , Samah Mohamed Taha , Mahmoud Abdelwahab Khedr', Feby Saad Attalla Mansour and Ayman Mohamed El Ashry Check Abstract Background Among people with bipolar disorders, there are high rates of impulsivity and suicide attempts Efforts to reduce suicide are hindered by the lack of conclusive evidence on interventional programs for those at risk Thus, this work evaluated the efficacy of acceptance and commitment therapy on impulsivity and suicidality among bipolar clients Methods In a randomized controlled trial, 30 eligible clients with bipolar disorders were given Acceptance and Commitment Therapy, and 30 eligible clients for the control group were chosen randomly at a 1 1 ratio using Research Randomizer version 4 0 Clients completed the Acceptance and Action Questionnaire II, the Short Arabic Version of the Impulsivity Behavior Scale, and the Arabic Version of the Beck Scale for Suicide Ideation Results It can be observed that there was a statistically significant decrement in the mean scores of psychological inflexibility among the study group between baseline value (TO), posttest measurement (T1), and post two month follow up (T2), from 32 91 SD (6 03) to 23 06 SD (6 22) post and 26 83 SD (3 49) post two months, with an effect size of 0 846 (P 0 001), compared to the control group, which revealed an increase in the mean score The overall impulsivity among the study group between TO, T1, and T2 was 61 27 SD (4 57) to 46 83 SD (4 47) post and 43 0 SD (5 30) post two months, with an effect size of 0 906 (P 0 001) Compared to the control group, which revealed a relative increase in the mean impulsivity score at the post and post two month intervals, the Arabic Versions of the Beck Scale for Suicide Ideation Scale mean score before the intervention was 16 33 SD (6 08), then the post was 7 23 SD (4 72), and the post two month mean was 10 13 SD (5 49) with an effect size of 0 878 (P 0 001) among the study group On the other hand, mean scores of suicide ideation among clients in the control group increased posttest and nearly returned to the same value after two months Conclusion For bipolar clients suffering from suicidal thoughts and impulsive behaviors, acceptance and commitment therapy, an emerging third wave behavior therapy, is an effective intervention Trial registration The study was registered retrospectively with reference number NCT05693389 on 23 1 2023, available at https clinicaltrials gov ct2 show NCT05693389 Keywords Acceptance and commitment therapy, Impulsivity, Suicidality, Bipolar disorders Introduction Suicide is a severe health problem, with a global mortal ity rate of 1 4 of all deaths Annually, more than 700,000 people commit suicide 1 One half to two thirds of all successfully completed suicides are caused by mood disorders According to a meta analysis, around 90 of suicide cases involved a mental illness, of which about 43 2 had some affective disorders, and 25 7 had prob lems with substance use 2 About 30 40 and 50 of patients with affective disorders had major depressive disorder (MDD) and bipolar disorder (BD), respectively 3 Bipolar disorder (BD), marked by recurrent manic hypomanic and depressive episodes, has several sub types, including bipolar I (BD I), bipolar II (BD II), and BD Not Otherwise Specified (BD NOS) 4 Bipolar dis order's rapid cyclical nature, mixed episodes of agitated depression, early onset, comorbidity with anxiety disor ders, and substance use disorders have all been identified as risk factors for suicide 5 Suicidal behavior has a wide variety of complex causes Although bipolar disorder (BD) is a significant trigger for suicide, suicidal behaviors cannot be fully explained by BD without the interaction of other factors, such as the severity of the illness, impulsivity, hopelessness, hostil ity, and aggression 6 The research looked at impulsivity as either a trait characteristic of BD that remained con stant throughout the disorder's progression or as a state dependent characteristic that fluctuated with the severity of the symptoms 7 Impulsiveness is more likely to be observed in people with remitted BD A general population study has shown that impulsivity predicts suicide attempts The high rates of impulsivity in bipolar disorders are also linked to sui cide attempts within that illness However, a recent com prehensive meta analysis of 70 trials revealed only minor impacts 8 Nonetheless, in the scientific literature, the connection between impulsivity and suicidal behavior is well estab lished It has been presumed that impulsivity facilitates the transition from suicidal ideation to a suicide attempt, and it has even been suggested that impulsivity is a more significant indicator of a suicide attempt than the pres ence of a specific suicide plan 9 The absence of conclusive evidence on interventional programs targeted at the at risk population is a criti cal limitation for reducing suicide and suicide attempts (e g , clients with a suicide attempt history) In addi tion, the lack of randomized clinical studies limits our understanding of current therapy's (RCTs) effectiveness Although some therapies have been demonstrated to be effective, it has been challenging to implement and spread these programs in routine clinical practice 10 Several studies have examined using cognitive behavior therapy (CBT) as a suicidality intervention some findings indicate it is successful Borderline personality disorder clients who report self harm respond well to dialectical behavioral therapy (DBT) 11 Additionally, acceptance and commitment therapy (ACT), known as the third wave of behavioral therapy, had positive effects on reducing suicidal ideation 12 On the other hand, Mor rison et al (2020) 13 investigated the different diag nostic effects of ACT on impulsive decision making and found that it can be utilized as a meta diagnostic treat ment for impulsive behaviors ACT may be helpful in the management of psychiatric diseases such as depressive episodes, eating disorders, borderline personality disorder, and psychosis, which are connected to an increased risk of suicide 14 The foun dation of ACT is the premise that people seeking treat ment are encouraged to embrace painful feelings rather than try to suppress or modify them 15 Moreover, ACT encourages psychological flexibility, acceptance of one's own experiences, and dedication to behaviors consistent with one's ideals ACT therapies focus on six key processes to improve psychological flexi bility engagement with the present moment, acceptance, defusion, self as context, value clarification, and commit ted action 16, 17 Therefore, we are dealing with a complicated, multifac eted, and multifactorial primarily psychological phenom enon marked by suffering and intolerable psychological pain, in which a person decides to end their life in a spe cific situation (insufferable, insoluble, interminable, ines capable, without a future or hope) 18 Psychiatrists face a massive challenge in predicting and preventing suicidal behavior in their clients, but it may also be one of the most accurate measures of how well their clinical care works In addition, high impulsivity scores are associated with increased overall functional impairment, a higher number of episodes with early onset, and a higher num ber of past suicide attempts, as well as increased sub stance intake 19 Thus, this study evaluated the efficacy of acceptance and commitment therapy on psychological inflexibility, impulsivity, and suicidality among bipolar clients Research hypothesizes Clients who engaged in acceptance and commitment therapy had less psychological inflexibility than the control group Clients who engaged in acceptance and commitment therapy had less impulsivity than the control group Clients who engaged in acceptance and commitment therapy had less suicidality than the control group Methods and materials Study design A randomized controlled trial was conducted between October 2022 and February 2023 Study setting The study was conducted at the Main University Hospi tal's psychiatric outpatient clinics affiliated with Alexan dria University's Faculty of Medicine The clinics offer free treatment to clients with mental diseases These treatments include mental health evaluation and diag nosis, pharmaceutical prescriptions, and counseling The intervention took place in the outpatient clinic, which was equipped with various rooms to accommodate the different needs of the patients The researchers chose a rehabilitation room with a quiet, welcoming, comfort able environment and a private and confidential space to demonstrate client therapy sessions The clinics are open three days a week (Sunday, Monday, and Tuesday) for cli ents with mental illnesses from 8 a m to 2 p m Participants sample size calculation and sampling technique The number of clients with bipolar disorders who regu larly visit psychiatric outpatient clinics ranges from one to four every day (216 to 864 clients 6 months), accord ing to hospital statistics for 2021 2022 The sample size was determined using the G Power Windows 3 1 9 7 pro gram, with the following criteria effect size 0 25, err a prob 0 05, power (1 err prob) 0 85, number of groups examined 2, and the number of measurements 3, fol lowing Sim, and Lewis (2012) 20 Thus, the study group contained 30 clients with a DSM 5 bipolar diagnosis, and the control group had a similar number Inclusion criteria Specific eligibility criteria were established to ensure par ticipants' suitability for the study These criteria included the requirement that clients must be at least 18 years old, able to communicate coherently and meaningfully, pos sess reading and writing abilities, and not have an ill ness that has persisted for over 10 years Their medical records were retrieved and reviewed to confirm the cli ent's eligibility Outpatients who met the criteria for type I or II bipolar disorder as outlined in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM V) were selected as subjects for the study through a random selection process 4 Exclusion criteria To ensure that bipolar disorders were not influenced by comorbid conditions, clients who exhibited chronic psy chotic symptoms, were diagnosed with psychotic comor bidity, or were found under the influence of drugs or alcohol were excluded from participation in this study The eligibility of potential participants was confirmed through a combination of direct questioning and review ing their medical records Random allocation Using Research Randomizer version 4 0, eligible clients with BD were given ACT therapy at a 1 1 ratio chosen randomly A software application generated random integers with a predefined group code After getting written consent from eligible participants, a structured interview to investigate each client's mood symptoms was conducted the enrolling investigators asked the clients to choose a number between 1 and 60 to deter mine their group assignment The trained researcher who prepared the software program and the enrolling inves tigators were not involved in any other trial operations therefore, the allocation was kept secret Throughout the trial, trained outcome assessors were blinded to group assignments The ACT intervention will consist of eight sessions delivered over eight weeks, with evaluations of outcomes at baseline, study completion, and two month follow up The flow chart for BD (Fig 1) shows that participants (n 30) got acceptance and commitment therapy (ACT) face to face for 8 weeks The immediate post treatment assessments were performed with all BD clients in the intervention and control groups (n 60) All participants completed the two month follow up posttest (30 from the intervention group and 30 from the control group) Tools for data collection The data for the current study was gathered using the fol lowing tools Tool I sociodemographic and clinical data, structured interview schedule The researchers developed this tool to elicit data from clients' sociodemographic characteristics, such as age and marital status It was also used to collect information about the person's level of education, the length of their first psychiatric visit, the length of their illness, the causes of previous episodes, and the medicines they were given El Sayed et al BMC Nursing (2023) 22 271 First contact at the psychiatric outpatient clinics screening for inclusion and exclusion criteria for baseline assessment of bipolar disorder (BD) Total Patient screened for inclusion and exclusion criteria (n 122) Page 4 of 14 Excluded patients (5) Clients refuse to take part in this study (15) Clients were recently substance users (23) Clients were participated in another CBT group (8) Clients unable to read and write (11) Clients had chronic BD for more than 10 years Intervention group who received routine care in the outpatient clinics and acceptance and commitment therapy sessions (n 30) 18 Bipolar disorders I 12 Bipolar disorders II Random Allocation (n 60) Patients with BD participated at post test after intervention (n 30) Complete data analysed (n 30) Follow Up after Control group who received routine care in the outpatient clinics (n 30) 19 Bipolar disorders I 11 Bipolar disorders II Patients with BD participated at immediately post test (n 30) Complete data analysed (n 30) Patients with BD participated at final post two month follow up test after intervention (n 30) Missing Patients (n 0) Analysis two month after intervention finished Patients with BD participated at final post two months follow up test (n 30) Missing Patients (n 0) Tool II acceptance and action questionnaire ii (AAQII) AAQII consists of seven items on a Likert type self report scale to measure psychological flexibility 21 Defusion, acceptance, and commitment to action are fundamental processes Following each item is a Likert scale with the options never true 1 to always true 7 Greater psychological inflexibility is indicated by higher scores, which fall within the 7 49 total score range, determined from the sum of the item responses Cron bach's alpha was 0 93, according to earlier studies 22 The scale we employed had a standard Arabic translation, and Cronbach's alpha was 0 81, indicating good internal consistency Tool III the short Arabic version of the UPPS P impulsivity behaviour scale SUPPS P consists of 20 items, initially developed by Whiteside Lynam (2001) 23 , to assess five aspects of impulsivity Positive Urgency, Negative Urgency, Lack of Perseverance, Lack of Premeditation, and Sensation Seeking Every one of the five aspects is evaluated using a 4 point Likert scale The Arabic version of SUPPS P was first back translated into Arabic by the writers Bteich, Berbiche, and Khazaal (2017) 24 after being profession ally translated from French into Arabic Based on Cron bach's coefficients, the results showed that the scale was reliable, ranging from 0 58 to 0 81 Moreover, the authors use confirmatory factor analysis (CFA) to examine the covariance matrix S UPPS P subscales showed statis tically significant associations Moreover, variations in the significance of the correlations ranged from 18 to 29, showing that the Arab short UPPS P is a reliable evalu ation tool with strong psychometric properties In our study, the scale showed good internal consistency with a 0 80 Tool IV the Arabic versions of the Beck scale for suicide ideation (BSSI) Beck et al (1979) developed the BSSI, a 19 item scale that measures how strong suicidal thoughts were the week before the test 25 Beck et al (1988) introduced the self reporting edition of the measure Each item is rated on an ordinal scale of 0 to 2 the total score ranges from 0 Table 1 Time Plan of the Session Session time plan (90 min) 5 min practicing mindfulness, examining the self and the external world 15 min Review previous concepts and challenges encountered by BD clients during skill demonstration 30 min The trained researcher will apply and dem onstrate the session's new concepts through videos 30 min Discussed the session's objective and skills with the dients and asked them to demonstrate the strategies they learned throughout the session 10 min homework assignments to 38 26 Individuals respond to the first five things that are excerpted If an individual replies positively to the fifth item (scores 1 and 2), he or she answers the remain ing items otherwise, the questionnaire is finished As a result, for data analysis, we used overall scale scores With a Cronbach's alpha range between 0 89 and 0 94 and a test retest coefficient of 0 79, we used the study of Alsalman Alansari (2019) to demonstrate satisfactory reliability 27 Also, the internal consistency of the scale in this study reveals its reliability with a 0 82 Procedure Ethics approval and consent to participate The Ethical Committee of Alexandria University's Faculty of Nursing reviewed and accepted the study proposal An agreement from the head of the psychiatric outpa tient clinics at the Main Alexandria University Hospital for Psychiatric Medicine and the Patients' Rights Protec tion Committee of the Ministry of Health and Popula tion's General Secretariat of Mental Health in Cairo was obtained to conduct the trial Following an explanation of the therapy's aims, each client participating in the ther apy provided informed written permission It was pro tected by keeping the client's identity and personal data confidential The client's right to decline or withdraw from the research at any moment was underlined Preparation A structured interview took 10 to 15 min to collect the baseline assessment data using the study scales SUPPS P and BSSI Pilot study In this study, five clients with BD were chosen randomly to determine clarity and any barriers encountered during data collection those individuals were eliminated from the main study The instruments were clear, intelligible, and valuable in the pilot study The Alpha Cronbach's test was used to determine the internal consistency of the study instrument Intervention phase The ACT intervention consists of five groups, each with six clients 28, 29 The ACT ses sions were 90 min long and held weekly for eight weeks During ACT, all clients continued their usual care (TAU), including receiving one or more mood stabilizers pre scribed by their usual psychiatrist, expert care coordina tion, and emotional support ACT therapy group sessions were face to face with two certified ACT psychiatric nurse researchers for five consecutive groups to design a framework for each session and, at the same time, work through exercises in response to the direct experiences of each group The sessions comprised two psychoeduca tional sessions and six skill training sessions in which cli ents acquired skills (see Table 1 for the session time plan) Phase I consisted of two sessions, with the first focus ing on the ACT session's general goals and expectations of participants The second session concentrated on psychoeducation topics concerning drugs, symptoms, and the history of the illness were thoroughly addressed to equip clients with the essential information required to comprehend BD Based on a treatment manual and applications of ACT developed by Hayes et al (1999), Bach Hayes (2002), Bloy, Oliver, Morris (2011), El Ashry et al (2021) 16, 30 32 on clients with psychosis, and O'Donoghue et al (2018) on clients with BD, the researchers created a psychoeducational module of the ACT strategy 28 In Phase II, clients attended six skill training sessions to learn ACT and therapy skills After cultural adaptation to the Egyptian context, a structured manual was given to the clients So, each session's main aims and materials were translated into Arabic Accordingly, each ACT ses sion's general and specific goals were established Accord ing to the ACT approach, the goal of the intervention was to help the person become more psychologically flexible (have a more accepting, thoughtful, and calm response to BD symptoms and related emotions and thoughts) so that they could act in line with their values The ACT intervention emphasizes psychoeducational methods for bipolar and mood disorders Each session focuses on a unique aspect of bipolar disorders, such as mania, stress, impulsivity, sadness, medication, talking with loved ones, and suicide Each session presents ACT techniques as an alternative response to bipolar disorder symptoms The ACT groups are meant to be collaborative, involv ing experiential activities throughout, a commitment to working towards a valued goal, and mindfulness exercises between sessions The intervention's exercises (such as brief mindful ness, defusion, and value clarification) highlight how participants may accidentally become caught up in struggling with their BD symptoms and distress and thus adopt maladaptive coping strategies such as impulsiv ity and suicide Activities were brief, and learning points were timed and structured to meet challenges Particular emphasis was placed on encouraging practice at home A prepared film of an actor portraying a man expressing obstacles in his life was used to demonstrate the meta phor's real world relevance and broad applicability We recognize that eight weeks is a relatively brief period for evaluating change This period is adequate for the practi cal aims of this study, as we are more concerned with the possible usefulness of the intervention than with its last ing consequences (see Table 2) The posttest phase was performed twice immediately following the end of all sessions and a two month follow up using S UPPS P and BSSI The control group As a control group, clients were randomly assigned to their respective groups and continued to receive their usual care (TAU), which included receiving one or more mood stabilizers and antipsychotics as recommended by their psychiatrist from the outpatient clinic Assessments and evaluations were conducted concurrently with the intervention group on the screening day and two months later at the end of the study It was worth mentioning that the control group was on a waiting list, as they received the same intervention as the study group after the trial finished The researchers contacted the clients through their phones and What's Up groups Data processing and analysis Data were put into the computer, and the IBM SPSS soft ware package, version 23 0, was used to analyze the data To compare two categories of normally distributed quan titative variables, the Student t test was used ANOVA with repeated measures followed by Bonferroni adjust ment for multiple comparisons between the three periods in each group The Shapiro Wilk test was used to verify the variable distribution's normality The Chi square test is used when categorical variables are compared between groups (Monte Carlo or Fisher Exact) A 5 level of sig nificance was applied to the obtained results Results The study found that most clients in the intervention group (56 7 ) and the control group (40 ) were between 30 and 39 Over half of the clients in both groups (63 3 in the intervention group and 56 7 in the control group) held a university degree Single clients accounted for 56 7 of the intervention group and 46 7 of the control group More than half of the clients in both groups had families with 2 to 4 members (53 ) Additionally, most clients in both groups (63 3 in the intervention group and 53 3 in the control group) considered their income sufficient (Table 3) In the intervention group, 36 7 of clients experienced bipolar disorder symptoms for less than a year, while only 20 were in the control group More than half of the par ticipants in both groups had been hospitalized one to five times (76 7 in the study group and 53 3 in the control group) Most clients in both groups reported no physical illnesses (70 in the intervention group and 60 in the control group) Treatment methods included ECT ses sions for 30 of participants in both groups and phar maceutical treatment for 70 There were no significant differences in sociodemographic and clinical character istics between the intervention and control groups, indi cating they were well matched (see Table 4) The baseline mean score of the AAQ II was 31 81 (SD 6 08) for the intervention group and 32 73 (SD 4 98) for the control group After the intervention, the intervention group's mean AAQ II score decreased significantly to 22 05 (SD 5 72), while the control group's mean score increased slightly to 33 43 (SD 5 26) Table 2 ACT intervention Sessions for Clients with Bipolar Disorders Session Objective Metaphors Psychoeduca To provide clients with an over Describing the expecta tion Over view of ACT expectations of participants Psycho education Discussion of a booklet and videotape about BD Session 1 Learning to be Present How to Feel and Be Here and Now Session 2 Defusing impulsivity and suicidal thoughts Session 3 A Review of Accep tance Goals, Purpose, and Process Suggestions view of ACT ACT expectations of participants tions from the therapy To be conscious about symp videotape about BD toms, drugs, and the history of the BD illness Topics concerning drugs, symptoms, and the history of the illness were thoroughly addressed to equip clients with the fundamental information required to comprehend BD To be conscious of what is going on around you To be aware of one's thoughts, feelings, and body sensations (ie, private experience) To differentiate between what is present on the inside and what is present on the outside, and to explain these processes without making a judgment Introduces the concept of the mind and how it generates linguistic processes (thoughts and delusions) To be able to distinguish be tween ideas and other internal feelings To acquaint clients with the sensation of trying to force un wanted thoughts and feelings away (ie, to identify the process of experiential avoidance) To demonstrate the inef ficiency and ineffectiveness of experiencing avoidance to the client To encourage acceptance as an alternative to personal experience based avoidance methods Noticing what's Content The researchers explained the ACT session's general goals The researchers demonstrated ACT expectations of participants The researchers demonstrated BD symptoms, drugs, and the history of the illness were thoroughly addressed to equip clients with the essential information required to comprehend BD The researchers demonstrated how vital features of ACT contribute Outside The World, You to psychological flexibility and cognitive defusion while dealing with and Me impulsivity and suicidal thoughts Noticing What's Inside Thoughts, Feelings, and Physical Sensations Why I Can't Be Here What's Distracting Noticing the room his Describing the Self and Another The clients were taught to focus on their surroundings rather than their inner experiences by the researchers (such as thoughts, feelings, and bodily sensations) The bag and card The tug of war with monster images Addressing the Verbal Network in the Mind Experiences and Thoughts Training Your Co Pilot Thoughts about the Bell Listening to Your Co pilot The Thoughts He Gives Me Passengers on Your Plane Unwanted Thoughts Unwanted Feelings Dropping the Rope Willingness Getting Rid of Thoughts What is Unwanted Meeting One Another's Co Pilots Standing with Yourself Dropping the Rope The researchers encouraged the client to look at his habitual emotional control agenda as a response to delusional ideas and their influence on life The choice point model was employed by the researchers to express this meaning and emphasize acceptance as a useful coping tool Discuss the idea of creative hopelessness in relation to the traditional emotional control agenda The researchers advise the client to set aside the negative ideas and concentrate on willingness These skills lead to self development I am feeling I am thinking The researchers employed mindfulness techniques to help the client connect with the present moment and develop psychological flexibility to deal with impulsivity and suicidal thoughts The researchers suggested that the client utilize the language of notic ing when referring to behaviour altered due to internal experiences of negative thoughts or other thoughts and emotions triggered through out the session, such as Im noting that Using the metaphor Passenger on Your Plane, the researchers made a video to explain to the client how delusional ideas come and fade from the standpoint of an observer The decision point model changed to illustrate how suicidal ideas and sources of fusion are related, as well as how they affect moving away from the life the client wishes to live The researchers instructed the client to perform exercises that distanced him from the imagined self in order to build a separation between them The client was asked to repeat all distance exercises, in cluding 1 am having the thought that and identifying your thoughts Table 2 (continued) Session Session 4 A Review of Self as Context Goals, Purpose, Objective For clients to become aware of the self as content (content you), and that the 'content you (thoughts of like I am etc ) Changes over time and 3 and Process Suggestions situations as do feelings, Session 5 Clarification of Personal Values Goals, Purpose, and Process Suggestions Session 6 physical sensations, and ather thoughts they are impermanent For clients to become aware of the self as constant (constant you) and that the 'constant you does not change over time it is permanent Identify meaningful, valued domains of life Define specific behavioural goals that align with those values Identify potential barriers to following through with valued based living To continue clarification of Moving Ahead value based goals with Commit ted Action Goals, Purpose, and Process Suggestions Metaphors I Am the Person Who Who is the You who notices The Constant You' Noticing Sharing Who I am Acting 101 Wisdom with Age Images of Youth I Have Survived Where Do I Want to Fly Defining My Next Destination Exploring New Terrain Flying South Choosing a Direction Goal Sharing Initial Discussion Regarding Values Clarification Chain Analyses of Client Behaviour Turbulence in Flight What Makes for a Rough To identify barriers to commit Ride ted action To increase committed action in goal completion, building patterns of committed action To increase the generalization of skills for valued living, with Willingness in Action Committed to a valued Path Flying in a Meaningful Direction with Turbu lence Are You Willing the intention of continued com Commitment mitted action upon completion of the protocol Statements Content By monitoring suicidal and negative thoughts on many occasions, the researchers were able to assist the client comprehend the various aspects of self conceptualization The researchers focused the client's attention to the contrast between the self who sees such thoughts and the negative thoughts that occur The researcher employed the metaphor of leaves on a stream by pre senting a film and asking the client to see their thoughts and feelings as leaves flowing down a stream without trying to halt or control them The contrast between the outcomes and components of self evalua tions and the self that assesses was developed and emphasized by the researcher In order to illustrate the distinction between ideas and self, the researcher employed the metaphor of a chessboard while playing the game with the client The researchers spoke with the client about how prior attempts to fight unpleasant thoughts impact and get in the way of achieving his goals and, in turn, his values The researcher assisted the client in considering potential values that could fulfil his life purpose The client's values were clarified and categorized with the use of a Bull's Eye worksheet by the researchers The researchers used the compass metaphor to explain to the client how values relate to goals and the distinction between value and goal The disparity between his prized area and his everyday activities as a re sult of his negative thoughts was the focus of the researchers' attention By using a worksheet based on the client's selected value from the Bull's eye, the researchers were able to assist the client in setting a SMART goal and encouraging him to act on his value rather than on irrational or unpleasant perspectives The researchers concentrated on values that were established using the Bully's eye The researchers have started to create an action plan for one of the value domains from the Bully's eye The dient made a list of specific activities (such as reading the Quran, praying, drawing, conversing with other individuals, practicing mindful walking in the garden, and engaging in some physical exercise) that are pertinent to his short term goals and consistent with the selected value, ranking them according to how challenging they are to complete The researchers kept track of any obstacles that may stand in the way of his attaining his objectives as well as how he handled them when they did Flying in a Meaningful Direction with Turbulence Are You Willing was the subject of a worksheet and video presented by the researchers This is a metaphor used to persuade the client to remain committed to the action plans despite obstacles The client's opinion on the ACT sessions was then asked out The difference between the two groups was significant, with a large effect size (t 6 020, p 0 001, n2 0 856) At the two month follow up, the intervention group's mean AAQ II score remained lower than the pre intervention score at 24 13 (SD 4 49), while the control group's mean score decreased slightly to 31 21 (SD 4 31) The dif ference between the two groups was significant with a medium effect size (t 3 124, p 0 014, n2 0 314) (see Table 5) There were no significant differences between the intervention and control groups regarding subscales or the overall S UPPS P score at the baseline assessment However, after the intervention sessions, the interven tion group demonstrated significant reductions in posi tive eagerness, negative urgency, lack of perseverance, lack of premeditation, and sensation seeking On the other hand, the control group did not show any signifi cant changes in subscales or the overall S UPPS P score The differences between the intervention and control groups were statistically significant for all subscales and the overall S UPPS P score, with large effect sizes (all p 0 001, n2 0 945) The intervention group maintained Table 3 Distribution of the studied cases regarding their sociodemographic data characteristics Sociodemographic and clinical characteristics Age 20 29 30 39 40 49 Intervention group (n 30) Control group (n 30) x P N N 8 26 7 17 56 7 4 13 3 1 3 3 9272 30 0 2144 MCP 0 574 12 40 0 23 3 6 7 50 Sex Female 18 60 0 12 40 0 2 400 0 121 Male 12 40 0 18 60 0 Education Secondary 6 20 0 University 19 63 3 17 Postgraduate 5 16 7 914 30 0 0 867 MCP 0 766 56 7 13 3 Occupation Employed 15 Unemployed Retired Marital status Single Married 541 50 0 15 14 46 7 15 3 3 550 50 0 0 994 MCP 1 000 50 0 0 0 Divorced 164 56 7 9 30 0 13 3 13 xm m 14 46 7 1 207 MCP 0 663 43 3 10 0 Family no 2 4 5 7 7 Income Enough in enough 622 16 53 3 16 12 40 0 13 6 7 6 m 53 3 0 477 MCP 1000 43 3 3 3 19 63 3 16 11 36 7 14 53 3 46 7 0617 0 432 x Chi square test MC Monte Carlo significant reductions in all subscales and the overall S UPPS P score even after a two month follow up, while the control group did not exhibit any significant changes (see Table 6) No significant differences were observed between the intervention and control groups regarding their BSI scores at the baseline assessment However, after the ACT sessions, the intervention group demonstrated a significant reduction in BSI scores, with a mean score of 7 23 (SD 4 72), compared to the control group's mean score of 14 43 (SD 4 26), at the post interven tion assessment The difference between the two groups was statistically significant (T 6 196, p 0 001), with a large effect size (n2 0 878) Additionally, the interven tion group maintained a significant reduction in BSI scores even after a two month follow up assessment, with a mean score of 10 13 (SD 5 49), compared to the control group's mean score of 13 37 (SD 4 31) The dif ference between the two groups remained statistically significant (T 2 536, p 0 014), with a medium effect size (n2 0 344) (see Table 7) Discussion This randomized controlled trial was one of the few studies examining ACT therapy's effectiveness in reduc ing suicidal ideation in people with bipolar disorders According to prior research, clients with bipolar type 1 are more likely to be impulsive Unexpectedly, impulsiv ity is a prominent trait of eurythmics, and it does not only appear during manic or depressive episodes 5 Impulsivity is linked to increased functional impairment, higher hospitalization rates, a higher risk of suicide, and illness severity in BP 33 Thus, we also investigated the effectiveness of ACT therapy on impulsivity as a second ary outcome According to our research, compared to standard of care alone, ACT therapy significantly reduced suicidal thoughts in bipolar clients and improved impulse control It can be explained that ACT therapy primarily focuses on experiential avoidance, the propensity to suppress unwanted thoughts or emotions to increase psychologi cal flexibility It helps clients find hope, cultivate a fulfill ing life, and learn mindfulness Table 4 Distribution of the studied cases regarding their clinical data Clinical data Intervention group (n 30) N Control group (n 30) N 6 P The onset of the disorder less than one year 11 36 7 6 20 0 5 632 MCP 0 138 1 5 7 23 3 11 36 7 5 9 6 20 0 2 6 7 10 20 6 20 0 11 36 7 No of admission 1 5 23 76 7 16 53 3 4 991 MCP 0 096 6 10 3 10 0 10 33 3 11 20 4 13 3 4 13 3 Physical illness Yes No 9 30 0 12 40 0 0 659 0417 21 70 0 18 60 0 Treatment Medications ECT 21 70 0 9 30 0 Family history Yes 16 53 3 No 14 46 7 x Chi square test MC Monte Carlo a 21 70 0 0 0 1,000 9 30 0 22 20 66 7 1 111 0 292 10 33 3 Table 5 Description of mean scores and standard deviations of Acceptance and Action Questionnaire II (AAQ II) among the Intervention and control groups at pre, post, and post two month of the ACT intervention Acceptance and Action t(p) Intervention group (n 30) Control group (n 30) Questionnaire M SD M SD Pre 31 81 6 08 32 73 post 22 05 5 72 33 43 4 98 526 0 679 (0 536) 6 020 ( 0 001) Post two month 24 13 4 49 31 21 431 3 124 (0 014) F 73 321 2431 0 001 0 190 0 856 0314 SD Standard Deviation independent t test F ANOVA with repeated measures 2 Partial Eta Squire statistically significant p value at 50 05 the more mean score reflected more in psychological inflexibility Clients with bipolar disorders in the intervention group also improved their psychological flexibility regarding their impulsive acts and suicidal thoughts compared to the control group That was consistent with a study by Pankowski et al (2017), who applied group acceptance and commitment therapy (ACT) for bipolar disorders they reported a highly significant improvement in psy chological flexibility among the intervention groups with a large effect size The ACT intervention focused primar ily on improving clients' responses to complex thoughts and feelings by modifying their relationships with them 29 One of the primary areas of ACT treatment is escape, also known as experiential avoidance Some of the most common psychological frameworks used to explain sui cide, particularly the entrapment cry of pain model, include pain escape as a critical factor 34 Mindful ness skills, acceptance of distress, and defusion from distressing thoughts can all help an individual cope with the discomfort of severe emotional pain Finally, iden tifying personal values and engaging in positive action aligned with these values may result in a more integrated individual, thereby improving well being 11 Similarly, Ducasse et al (2018) 14 , in a randomized controlled trial comparing a 7 week relaxation group ver sus acceptance and commitment therapy as an add on to standard care for adult outpatients with a current suicidal behavior disorder, found that at the post therapy assess ment, the rate of change in ACT for suicidal ideation was higher than in the relaxation group 12 In a quasi exper imental study, Ghadam et al (2020) examined the impact of ACT therapy on reducing suicidal ideation in addi tion to anxiety and depressive symptoms They discov ered that ACT significantly helped manage and reduce suicide ideation, anxiety symptoms, and depressive symptoms in the experimental group 15 Najafi Arab Table 6 Description of mean scores and standard deviations of The Arab S UPPS P impulsivity scale among the intervention and control groups at pre, post, and post two month of the ACT intervention The Arab S UPPS P impulsivity scale Intervention group (n 30) Control group(n 30) T (p) M SD M SD Positive eagerness Pre 11 67 1 84 11 47 3 40 0 283 (0 778) Post 9 30 2 49 12 70 3 98 3 962 ( 0 001) Post two month 8 27 241 11 73 2 68 5 275 ( 0 001) F Negative urgency Lack of perseverance Pre Post Post two month 9 0 9 3 (P) n Pre Post 22 053 1,003 0 001 0 373 0 611 0 049 12 93 1 66 13 37 3 20 0 658 (0 513) 10 23 1 57 12 77 3 89 3 306 (0 002 ) 215 12 13 2 57 5 123 ( 0 001) 50,840 1275 0 001 0 287 0 668 0 103 10 97 279 10 40 1 85 0 928 (0 357) 9 17 248 10 87 1 63 3 136 (0 003) 1 73 10 87 1 91 4 681 ( 0 001) Post two month 867 F 29 088 2 355 0 001 0 104 0577 0 119 12 67 2 20 11 50 276 1,808 (0 076) 7 30 1 73 11 80 1 86 9 704 ( 0 001) Lack of premeditation Pre Post Post two month 7 0 1 80 11 60 2 22 8 810 ( 0 001) F 276512 0372 0 001 0 691 0 945 0 026 Sensation seeking Pre 13 03 1 83 12 97 3 35 0 096 (0 924) Post 10 83 1 42 13 57 3 58 3 890 ( 0 001) Post two month 10 07 F n2 Overall S UPPS P Pre Post Post two month 43 0 F (P) zu 277 13 17 16437 0 388 0 001 0 680 0 560 0 013 61 27 4 57 59 70 766 0 962 (0 340) 46 83 447 61 70 7 35 9469 ( 0 001) 5 30 59 93 181 569 0 001 0 906 3 05 4 122 ( 0 001) 640 11 158 ( 0 001) 1 090 0 343 0 058 SD Standard Deviation independent t test F ANOVA with repeated measures 2 Partial Eta Squire statistically significant p value at 50 05 (2020) reported that ACT Therapy can improve psycho logical capital and emotion regulation in people with sui cidal ideation, so it is recommended to reduce suicidal thoughts 35 Conversely, Torok et al (2020) confirmed that studies that directly addressed suicide showed the most significant reductions in suicidal ideation, whereas indirect interventions aimed at treating depression did not 36 After reviewing 44 studies, Meerwijk and col leagues concluded that indirect interventions had no appreciable short term impact on suicide 37 Table 7 Description of mean scores and SD of The Arabic versions of the Beck Scale for Suicide Ideation (BSI) among the intervention and control groups at pre, post and post two month of the ACT intervention Beck scale for Suicide ideation Total (B5) Intervention group (n 30) Control group (n 30) T (p) M SD M SD Pre Post 16 33 6 08 13 73 3 98 1 809 (0 076) 7 23 4 72 14 43 4 26 6 196 ( 0 001) Post two month 10 13 5 49 13 37 4 31 2 536 (0 014) F (P) 70 321 4 222 0 001 0 019 0 878 0344 SD Standard Deviation independent t test F ANOVA with repeated measures 2 Partial Eta Squire statistically significant p value at 50 05 Our results were in line with Polat Karaka (2021), who conducted a randomized control trial to examine the impact of ACT therapy oriented anger management training on anger rumination and impulsivity levels in individuals receiving forensic mental healthcare They discovered that the experimental group's total scores on the Barratt Impulsiveness and Anger Rumination Scales were significantly lower than those of the control group 38 In this context, Baghani Akbari (2020) confirmed that cognitive defusion, the effect of thought (such as the desire to use) on behavior in acceptance and commit ment therapy, can explain why ACT therapy effectively reduces the impulsivity components of women who abuse drugs Behavior dependent on context or thought is categorized as cognitive fusion or cognitive defusion, and when a person is fused with their thoughts, they can not discriminate between their mental judgment and reality 39 Hasani, Hasani, Niaei (2019) reported that through increased awareness, psychological acceptance, emotional isolation, emotion management, a reduction in ineffective control, and problem solving techniques, ACT therapy lessens the impulsivity of clients with bipo lar disorders and major depressive disorder 40 Morri son et al (2020) investigated the efficacy of ACT therapy in impulsive decision making The findings indicated that this therapy increased productivity and flexibility in emo tions, thoughts, and physical states and that the ACT was a valuable therapy for helping people change their behav ior and improve their quality of life 13 Hayes et al (2012) explained that ACT therapy helps clients accept their uncontrolled emotions and cogni tions and be spared from regulating the linguistic rules that have caused those troubles rather than remov ing damaging variables This treatment strategy aims to lessen impulsivity by fostering psychological flexibility on the one hand and acting on personal values on the other, and it assists clients in building an entire, meaningful life 41 Developing a self observer in clients through defu sion skills, mindfulness, and present moment awareness is another aspect of this therapy that aids in reducing impulsivity Mindfulness can help increase awareness of automatic thoughts, enhancing a person's ability to assess the potential implications of actions before engaging in them 42 Limitations The study's follow up period only lasted two months after the intervention, which means that any long term effects of the treatment could not be evaluated Addi tionally, cultural differences may exist in understanding concepts such as acceptance, defusion, and metaphors, which should be considered when interpreting and gen eralizing the study's results Therefore, caution should be exercised when drawing broader conclusions from the study As the small sample size was a significant limita tion and could affect the study's statistical power and generalizability, it was recommended to do other studies with large sample sizes Conclusions Even though our study sheds light on the efficacy of ACT on impulsivity and suicidality among clients with bipo lar disorders in a specific ethnocultural group, due to the small sample size and cultural specificity, care should be taken when generalizing our results to other populations To replicate and build on our findings and investigate the significance of culturally specific elements in the con nection between impulsivity and suicidal behavior, addi tional research with more extensive and diverse samples is required The ACT intervention is an effective inter ventional strategy for bipolar disorder clients to lessen suicidal thoughts and impulsive behaviors, so it is essen tial and apparent that the fundamental ACT principles be applied to these clients Nursing implications In outpatient clinics, ACT must be a more prominent intervention for at risk clients with BD who make impul sive decisions and suffer recurrent suicidal thoughts Therefore, ACT may lessen the severity and or frequency of suicidal ideations through several mechanisms, includ ing improving acceptance skills due to a shift in the cli ent's connection to their internal experiences and clarity of what is significant in their lives Life becomes more meaningful through increased personal commitment to behaviors that uphold values A negative effect on modi fiable suicide risk variables (impulsivity, hopelessness, and psychological suffering) Abbreviations ACT BD Acceptance and Commitment Therapy Bipolar Disorders Beck Scale for Suicide Ideation Received 2 May 2023 Accepted 9 August 2023 Published online 17 August 2023 BSI RCT Randomized Control Trial S UPPUS P TAU Short Arabic Version of the UPPS P Impulsivity Behavior Treatment as Usual Acknowledgements The authors thank all participants who accepted to be part of this work Authors' contributions Mona Metwally El Sayed conceptualization, preparation, and Implementation of the sessions, methodology, investigation, writing original draft, writing review editing Eman Sameh Abd Bhay Methodology, investigation, formal analysis, data analysis, writing original draft, writing manuscript editing Samah Mohamed Taha conceptualization, methodology, investigation, formal analysis, data analysis, writing original draft, writing manuscript editing Mahmoud Abdelwahab Khedr conceptualization, preparation, and Implementation of the sessions, methodology, investigation, writing original draft, writing manuscript editing Feby Saad Attalla Mansour conceptualization, methodology, investigation, writing original draft, writing manuscript editing All authors read and approved the final manuscript Ayman Mohamed El Ashry conceptualization, preparation, and Implementation of the sessions, methodology, investigation, formal analysis, data analysis, writing original draft, writing manuscript editing All authors reviewed the manuscript and accept for publication Funding Open access funding provided by The Science, Technology Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank EKB) Data Availability On reasonable request, data will be available from the corresponding author layman el ashry alexu edu eg) Declarations Ethical considerations and consent to participate All steps followed the relevant guidelines and regulations of the Declaration of Helsinki (DoH Oct 2006) The study proposal has been reviewed by the Ethical Committee of the Faculty of Nursing Alexandria University It was approved (IRB00013621 64 9 2022) in September 2022 as a condition for proceeding with the current research Along with agreement from the head of the psychiatric outpatient clinics at the Main Alexandria University's Hospital for Psychiatric Medicine and the agreement of the Patients' Rights Protection Committee of the Ministry of Health and Population's General Secretariat of Mental Health in Cairo (code 988 2022), following an explanation of the therapy's aims, each dient participating in the therapy provided informed written consent Consent for publication Not applicable Competing interests The authors declare no competing interests Author details 'Psychiatric and Mental Health Nursing, Faculty of Nursing, Alexandria University, Alexandria, Egypt Psychiatric and Mental Health Nursing, Faculty of Nursing, Mansoura University, Mansoura, Egypt Physiopsychology, Department of Psychology, Faculty of Arts, Alexandria University, Alexandria, Egypt References 1 World Health Organization Suicide worldwide in 2019 global health estimates 2021 (Available from https apps who int iris bitstream han dle 10665 341728 9789240026643 eng pdf 2 3 4 5 6 Chou P H, Ito M, Horikoshi M Associations between PTSD symptoms and suicide risk a comparison of 4 factor and 7 factor models J Psychiatr Res 2020 129 47 52 https doi org 10 1016 j jpsychises 2020 06 004 Valtonen H, Suominen K, Mantere O, Leppamaki S, Arvilammi P, Isometsa ET Suicidal ideation and attempts in bipolarl and I disorders J Clin Psychiatry 2005 66(11) 1456 62 https doi org 10 4088 JCPv66n1116 American Psychiatric Association, Association D AP Diagnostic and statistical manual of mental disorders DSM 5 American psychiatric association Wash ington, DC 2013 Zakowicz P, Skibiska M, Wasicka Przewona K, Skulimowski B, Waniewski F, Chorzepa A, et al Impulsivity as a risk factor for suicide in bipolar disorder Front Psychiatry 2021,12706933 https doi org 10 3389 fpsyt 2021 706933 Abreu LNd, Lafer B, Baca Garcia E, Oquendo MA Suicidal ideation and suicide attempts in bipolar disorder type t an update for the clinician Brazilian J Psy chiatry 2009 31 271 80 https doi org 10 1590 S1516 44462009005000003 7 Spoorthy MS, Chakrabarti S, Grover S Comorbidity of bipolar and anxiety disorders an overview of trends in research World J psychiatry 2019,9111 7 https doi org 10 5498 jp9i17 8 Johnson SL, Carver CS, Tharp JA Suicidality in bipolar disorder the role of emotion triggered impulsivity Suicide Life Threatening Behavior 2017 47(2) 177 92 https doi org 10 1111 sltb 12274 9 Gvion Y, Levi Belz Y, Hadlaczky G, Apter A On the role of impulsivity and decision making in suicidal behavior World J psychiatry 2015,5(3) 255 https doi org 10 5498 wpv5 13 255 10 Mndez Bustos P, Calati R, Rubio Ramirez F, Oli E, Courtet P, Lopez Castro man J Effectiveness of psychotherapy on suicidal risk a systematic review of observational studies Front Psychol 2019 10 277 https doi org 10 3389 fpsyg 2019 00277 11 Tighe, Nicholas J, Shand F, Christensen H Efficacy of acceptance and commitment therapy in reducing suicidal ideation and deliberate self harm a systematic review JMR mental health 2018521e10732 https doi org 10 1016 52589 7500(19)30199 2 12 Bahlmann L Lbbert MB, Sobanski T, Kastner UW, Walter M, Smesny S, et al Relapse Prevention intervention after suicidal event (RISE) feasibility study of a psychotherapeutic short term program for inpatients after a recent suicide attempt Front Psychiatry 2022,13 https doi org 10 3389 fpsyt 2022 937527 13 Morrison KL, Smith BM, Ong CW, Lee EB, Friedel JE, Odum A, et al Effects of acceptance and commitment therapy on impulsive decision making Behav Modif 2020,44 4)600 23 https doi org 10 1177 0145445519833041 14 Ducasse D, Jaussent, Arpan Brand V, Vienot M, Laglaoui C, Bziat S, et al Acceptance and commitment therapy for managing suicidal patients a ran domized controlled trial Psychother Psychosom 2018,87(4 211 22 https doi org 10 1159 000488715 15 Ghadam HSH, Rahnejat AM, Taghva A, Ebrahimi MR, Donyavi V, Ghasemzadeh MR Effectiveness of acceptance and commitment therapy in reducing anxi ety, depression, and suicidal ideation in iranian veterans referred to a military psychiatric hospital 2020 https doi org 10 13140 RG 2 2 34978 07369 1 16 Hayes SC, Strosahl KD, Wison KG Acceptance and commitment therapy Guilford Press New York 1999 17 Hinrichs KL, Steadman Wood P Meyerson JL ACT now the intersection of Acceptance and Commitment Therapy with palliative care in a veteran with chronic suicidal ideation Clin Gerontologist 2020 43(1) 126 31 https doi org 10 1080 07317115 2019 1642974 18 Fonseca Pedrero E, Al Halabi S Suicidal behavior prevention the time to act is now Clinica y Salud 2021 32(2) 89 92 https doi org 10 5093 dysa2021a17 19 Strasser ES, Haffner P, Fiebig J, Quinlivan E, Adi M, Stamm TJ Behavioral measures and self reported impulsivity in bipolar disorder no association between Stroop test and Barratt Impulsiveness Scale Int J Bipolar Disorders 20164(1) 1 10 https doi org 10 1186 s40345 016 0057 1

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El-Sayed et al BMC Nursing (2023) 22:271 https://doi.org/10.1186/s12912-023-01443-1 RESEARCH BMC Nursing Open Access Efficacy of acceptance and commitment therapy on impulsivity and suicidality among

El-Sayed et al BMC Nursing (2023) 22:271 https://doi.org/10.1186/s12912-023-01443-1 RESEARCH BMC Nursing Open Access Efficacy of acceptance and commitment therapy on impulsivity and suicidality among clients with bipolar disorders: a randomized control trial Mona Metwally El-Sayed', Eman Sameh Abd Elhay?, Samah Mohamed Taha?, Mahmoud Abdelwahab Khedr', Feby Saad Attalla Mansour and Ayman Mohamed El-Ashry* Check Abstract Background Among people with bipolar disorders, there are high rates of impulsivity and suicide attempts. Efforts to reduce suicide are hindered by the lack of conclusive evidence on interventional programs for those at risk. Thus, this work evaluated the efficacy of acceptance and commitment therapy on impulsivity and suicidality among bipolar clients. Methods In a randomized controlled trial, 30 eligible clients with bipolar disorders were given Acceptance and Commitment Therapy, and 30 eligible clients for the control group were chosen randomly at a 1:1 ratio using Research Randomizer version 4.0. Clients completed the Acceptance and Action Questionnaire II, the Short Arabic Version of the Impulsivity Behavior Scale, and the Arabic Version of the Beck Scale for Suicide Ideation. Results It can be observed that there was a statistically significant decrement in the mean scores of psychological inflexibility among the study group between baseline value (TO), posttest measurement (T1), and post-two-month follow-up (T2), from 32.91 SD (6.03) to 23.06 SD (6.22) post and 26.83 SD (3.49) post-two months, with an effect size of 0.846 (P

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