Question
esearchers conducted a clinical trial to assess whether Treatment X would effectively reduce the risk of a myocardial infarction in patients with significant arterial calcification.
esearchers conducted a clinical trial to assess whether Treatment X would effectively reduce the risk of a myocardial infarction in patients with significant arterial calcification. However, the trial was stopped due to an observed increase in the risk of death for patients assigned to receive Treatment X compared to the placebo treated group. Furthermore, it is well established that older age further increases an individual's risk of a myocardial infarction;therefore, the researchers were interested in determining if the increased risk of death due to Treatment X was only present in the older patients. The table below presents their data.
Age (years) | Total | |||||
< 55 | > 55 | |||||
X | Placebo | X | Placebo | X | Placebo | |
Deaths | 8 | 5 | 22 | 16 | 30 | 21 |
Total at Risk | 106 | 120 | 98 | 85 | 204 | 205 |
Risk of Death | 0.076 | 0.042 | 0.224 | 0.188 | 0.147 | 0.102 |
Risk Difference | 0.034 | 0.036 | 0.045 | |||
Risk Ratio | 1.81 | 1.19 | 1.44 |
Evaluate the potential of effect modification by age on the relationship between treatment X and death. What measure of association would you report for this study? Assume that 10% constitutes a meaningful difference to evaluate whether effect modification is present
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