Question
You have been given a primary amine and a coupling agent (salicylic acid and 2-aminobenzene-sulfonic acid), starting materials for a parallel synthesis reaction. Diazotization
You have been given a primary amine and a coupling agent (salicylic acid and 2-aminobenzene-sulfonic acid), starting materials for a parallel synthesis reaction. Diazotization of aminobenzenesulfonic acid In an 18 x 150 mm test tube, dissolve 0.49 g of 2-aminobenzenesulfonic acid in 5 mL of 2.5% Na2CO3 solution. Place the test tube in a beaker of boiling water on a hot plate and stir to completely dissolve the solid. Cool the solution under the tap, and then add 0.2 g of sodium nitrite, NaNO2. Stir until it is dissolved. Add this solution dropwise to a 25 mL flask that contains about 3 g of ice and 0.53 mL of concentrated HCI. a. calculate the number of grams of coupling agent needed to carry out the reaction.
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Authors: Jerald E Pinto, CFA Institute
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1119850517, 978-1119850519
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