Question
For the following peptide chain WHD (Tryptophan-Histidine-Aspartic acid) : pH = 8 Given pKa value for W : Alpha carboxy = 2.38 + Alpha Amino
For the following peptide chain WHD (Tryptophan-Histidine-Aspartic acid) : pH = 8
Given pKa value for W :
Alpha carboxy = 2.38
+ Alpha Amino = 9.39
Given pKa value for H:
Alpha carboxy = 1.82
+ Alpha Amino = 9.17
Side chain = 6.04
Given pKa value for D :
Alpha carboxy = 2.09
+ Alpha Amino = 9.82
Side chain = 3.86
a. what is the charge of each amino acid residue
b. what is the net charge on the whole protein at pH=8
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Spectrometric Identification Of Organic Compounds
Authors: Robert M Silverstein, Francis X Webster, David J Kiemle, David L Bryce
8th Edition
0470616377, 9780470616376
