For this exercise assume that the pharmacokinetic data reported in the document reflect the population mean () and population standard deviation (?).

3. What percent of patients treated will have a Cmax level below 1.3 ug/ml when treated with VEKLURY (100 mg IV dose)?Table 12 Multiple Dose PK Parameters of Remdesivir and Metabolites (GS-441524 and GS- 704277) Following IV Administration of VEKLURY 100 mg to Healthy Adults Parameter Remdesivir GS-441524 GS-704277 Mean (CV%) Cmax (nanogram per mL) 2229 (19.2) 145 (19.3) 246 (33.9) AUCtau 1585 (16.6) 2229 (18.4) 462 (31.4) (nanogram.h per mL) Ctrough ND 69.2 (18.2) ND (nanogram per mL) CV=Coefficient of Variation; ND=Not detectable (at 24 hours post-dose) a. Remdesivir administered as a 30-minute IV infusion (Study GS-US-399-5505)