Generally, in capital budgeting process (or referring to Orchard Biotech Company problem above):

A) what is/are possible weakness(es) of using NPV as your primary decision tool and how these can be addressed?

B) what is/are possible weakness(es) of using IRR as your primary decision tool and how these potential problems can be addressed?

C) explain scenario(s) when you might be willing to accept a project with nominally worse metrics (i.e., worse NPV or IRR)