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Given the toxicity dose-response data collected in a laboratory experiment Dose (mg/kg) 10 22 35 78 112 169 310 580 1020 Response (R = %)

Given the toxicity dose-response data collected in a laboratory experiment

Dose (mg/kg)

10

22

35

78

112

169

310

580

1020

Response (R = %)

8

18

27

41

52

63

78

91

100

Log Dose (Ld #)

2.30

3.09

3.56

4.36

4.72

5.13

5.74

6.36

6.93

Calculate

1 - Plot the Cumulative Linear dose-response curve (graph 1)

2 - Model the logarithmic trendline (graph 2)

2.1 - Use the logarithmic trendline equation provided by Excel to calculate ED10

2.2 - Calculate RfD; use ED10 as the NOAEL

3 - Plot the Cumulative - Log dose response curve (graph 3)

4 - Model the Cumulative - Log dose response curve to a linear regression (graph 4)

From the linear regression trendline obtained from Excel

Calculate the dose for a

1.0E-04

probability of Response

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