Question
Given the toxicity dose-response data collected in a laboratory experiment Dose (mg/kg) 10 22 35 78 112 169 310 580 1020 Response (R = %)
Given the toxicity dose-response data collected in a laboratory experiment | ||||||||||||
Dose (mg/kg) |
| 10 | 22 | 35 | 78 | 112 | 169 | 310 | 580 | 1020 | ||
Response (R = %) |
| 8 | 18 | 27 | 41 | 52 | 63 | 78 | 91 | 100 | ||
Log Dose (Ld #) |
| 2.30 | 3.09 | 3.56 | 4.36 | 4.72 | 5.13 | 5.74 | 6.36 | 6.93 | Calculate | |
1 - Plot the Cumulative Linear dose-response curve (graph 1) | ||||||
2 - Model the logarithmic trendline (graph 2) | ||||||
2.1 - Use the logarithmic trendline equation provided by Excel to calculate ED10 | ||||||
|
| |||||
|
| |||||
|
| |||||
2.2 - Calculate RfD; use ED10 as the NOAEL | ||||||
3 - Plot the Cumulative - Log dose response curve (graph 3) | ||||||
4 - Model the Cumulative - Log dose response curve to a linear regression (graph 4) | ||||||
From the linear regression trendline obtained from Excel | ||||||
Calculate the dose for a | 1.0E-04 | probability of Response |
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started