Hello tutors, all answers must be correct and detailed.

Marketing case study, The case describes AXA's corporate responsibility (CR) function. The company, a global leader in insurance and asset management, had distinguished itself in CR since formally establishing a CR unit in 2008. As the case opens, AXA's CR unit is being moved from the marketing function to the strategy group occasioning a thorough review as to how CR should fit into AXA's operations and strategy. Students are asked to identify CR issues of particular concern to the company, examine how addressing these issues would add value to the company, and then create metrics that would capture a business unit's success or failure in addressing the concerns.

1 Please could you explain how lymphocytes (especially B) can maintain receptors on their surfaces? Is this genetically related? If so, when the lymphocytes are first exposed to the antigens, how could the antigen receptor be synthesized? Is there a mutation within the nuclei of these lymphocytes when they learn to make the receptors? If there is, can you explain how this occurs?

2 I understand how nuclear factor-B (NFB) works in the inflammatory response but what is the mechanism by which it causes cancer?

3 What are the diseases associated with hypocomplementaemia and which complement deficiency in particular?

4 What is meant by 'B lymphocytes are sensitive to clonal deletion'?

5 What are the immunological implications of 'bare lymphocyte syndrome'/MHC deficiency?

6 Please explain oligoclonal and monoclonal.

7 I was wondering if there is any study regarding cell culture techniques of CD4 helper cells (stem cell culturing) and, if so, is it of any benefit to HIV-infected patients?

8 How do you define autoimmune disease?

9 1. Why is dexamethasone not routinely used instead of prednisolone, which is almost universally used routinely in autoimmune diseases, or other indications for steroids? Is it because dexamethasone lacks the mineralocorticoid activity seen with prednisolone and therefore does not cause salt/water retention and hypertension?

2. Can high doses of dexamethasone be used in acute relapses of multiple sclerosis (MS) in place of pulse methylprednisolone? If so, what is the recommended dosage?

10 What is meant by 'pus cell' and is this term synonymous with neutrophils?