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11 Fill in the Blank 4 points A choose your answer... can hydrolyze ATP to add a phosphate to another protein, a choose your answer... can remove that phosphate. In contrast in GTPases a choose your answer... causes the GTPase itself to hydrolyze GTP and a choose your answer... removes the GDP and adds a new GTP. 12 Fill in the Blank 1 point Often GTPases and kinases work together as in this RAS signaling pathway. RAS leads to cell proliferation. More than 30% of cancers have a mutation in a RAS protein. The mutations cause it to be bound to choose your answer... all the time. Therefore it is always choose your answer... The mutation causes it to have a very low GTP hydrolysis rate. 13 Multiple Choice 1 point How does GTPase activity alter the activity of RAS. That is, why do the GTP bound and GDP bound protein have different functions? O It changes the protein's conformation so alters its function. It controls the enzyme allosterically It blocks the active site O GTP is necessary to drive the reaction forward