heparin Drip Protocol Heparin Mix = 20,000 units heparin in 500 mL D5W. or 6 hours after each Heparin dose change. notify physician (bolus 80 u /Kg & increase rate 4 units/kg). 35-45, 40 u /Kg bolus & increase by 2 units Kg / hour. 6-70, maintain the current infusion rate. 1-90, decrease the rate by 3 units /Kg per hour. top the drip x 1 hour, notify physician