Hepatic Cirrhosis is a rare disease (less than 10 cases per 100,000) that affects the liver. Suppose you want to study the association between alcohol consumption and Hepatic Cirrhosis. Which of the following is the most suitable way to study the association? MCQ

a) I would design a case-control study. I would randomly select 1000 Hepatic Cirrhosis patients and 1000 healthy individuals. Then I will look into the alcohol consumption habits. This way, I can estimate the population odds ratio.

b) I would design a case-control study. I would randomly select 1000 Hepatic Cirrhosis patients and 1000 healthy individuals. Then I will look into the alcohol consumption habits. This way, I can estimate the population risk ratio.

c) I would design a cohort study. I would randomly select 1000 people who consume alcohol regularly and 1000 people who do not consume alcohol at all. Then I will follow them over the years and see how many percent of people in each group would develop Hepatic Cirrhosis. This way I can estimate both the population risk and odds ratio.