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1 -Age of Onset and Family Histories of Individuals with Bipolar Disorder

In their paper "Early Age at Onset as a Risk Factor for Poor Outcome of Bipolar Disorder", Journal of Psychiatric Research, (2003), Carter et al. one of the relationships examined was that between age of onset (early age 18, later age > 18) and family history of mood disorders. This paper is linked to the D2L site under categorical data analysis in the outline. Some the results from their study are contained in the files:Bipolar Family.JMP for part (a) andBipolar Episode.JMPfor part(b).

Family History of Mood Disorders	Age of Onset	Row Totals
Early (age 18) (E)	Later (age > 18) (L)
Negative (A)	28	35	63
Bipolar disorder (B)	19	38	57
Unipolar (C)	41	44	85
Unipolar/bipolar (D)	53	60	113
Column Totals	141	177	n = 318

a) Use these data to determine if there is a relationship between age of onset and family history for the population of individuals with bipolar disorder. Summarize your findings. (4 pts.)

Mosaic Plot 1.00 0.75 49.4% 55.6% 54.7% L 55.7% 66.7% Age of Onset 0.50 0.25 50.6% 44.4% 45.3% E 44.3% 33.3% A B C D Family History - Contingency Table Tests N DF -LogLike ASquare (U) 318 3 2.0996953 0.0096 Test ChiSquare Prob>ChiSq Likelihood Ratio 4.199 0.2407 Pearson 4 135 0.2472Mosaic Plot 1.00 33.3% 0.75 45.9% L 51.4% 75.0% Age of Onset 0.50 66.7% 0.25 54.1% E 48.6% 25.0% D H M Episode - Contingency Table Tests N DF -LogLike RSquare (U) 222 2 8.5740346 0.0557 Test ChiSquare Prob>ChiSq Likelihood Ratio 17.148 0.0002* Pearson 16.503 0.0003*Mosaic Plot 1.00 7.19% 24.29 0.75 Baseline Testa7 0.50 08.75% 92 9% 75.09 0.25 AFP FP IM MG Practice Type Frog: Freq Contingency Table Tests N DF -LogLike ASquare (U] 10144 3 310.17393 0.1292 Test ChiSquare ProbeChiSq Likelihood Ratio 620.348 20001* Pearson 816.410 0001Practice Type=AFP Practice Type=FP Baseline Tests? Baseline Tests? Frequencies Frequencies Level Count Prob Level Count Prob N 3064 0.98394 N 2862 0.96689 50 0.01606 y 98 0.03311 Total 3114 1.00000 Total 2960 1.00000 N Missing N Missing 2 Levels 2 Levels Confidence Intervals Confidence Intervals Level Count Prob Lower Cl Upper CI 1-Alpha Level Count Prob Lower Cl Upper CI 1-Alpha N 3064 0.98394 0.978895 0.987799 0.950 N 2862 0.96689 0.959817 0.972756 0.950 50 0.01606 0.012201 0.021105 0.950 98 0.03311 0.027244 0.040183 0.950 Total 3114 Total 2960 Note: Computed using score confidence intervals. Note: Computed using score confidence intervals. Practice Type=IM Practice Type=MG Baseline Tests? Baseline Tests? Baseline Tests?: Y N: 294 N Frequencies Frequencies Level Count Prob Level Count Prob N 921 0.75802 N 2652 0.92890 294 0.24198 203 0.07110 Total 1215 1.00000 Total 2855 1.00000 N Missing 0 N Missing 2 Levels 2 Levels Confidence Intervals Confidence Intervals Level Count Prob Lower Cl Upper CI 1-Alpha Level Count Prob Lower Cl Upper CI 1-Alpha N 921 0.75802 0.733154 0.781269 0.950 N 2652 0.92890 0.918882 0.937759 0.950 Y 294 0.24198 0.218731 0.266846 0.950 203 0.07110 0.062241 0.081118 0.950 Total 1215 Total 2855 Note: Computed using score confidence intervals. Note: Computed using score confidence intervals.1-2 drinks/week 1.00 20.5% 22.7% Y 21.096 Mosaic Plot 1.00 0.75 20.5% rtion 0.75 0.50 Spontaneous A 79.5% 77.3% N 79.096 Spontaneous Abortion 0.50 0.25 79.5%% N a None b 1-2 Alcohol Use (drinks/week) a None c 3- q: Freq Alcohol Use (drinks/week) Contingency Table q: Freq Spontaneous Abortion Contingency Table Count N Total Row % Spontaneous Abortion Count N 2637 Total 6793 33164 Total 9% Alcohol Use 79.52 20.48 Col % 7031 2068 9099 Row 9% 77.27 22.73 26371 6793 33164 Total 33402 8861 42263 72.78 18.75 91.53 92.00 89.75 Tests 79.52 20.48 C 3-6 2293 776 3069 DF -LogLike RSquare (U) 6.33 2.14 8.47 Alco 42263 10.701522 0.0005 8.00 10.25 74.71 25.29 Test ChiSquare Prob>ChiSq Total 28664 7569 36233 Likelihood Ratio 21.403 <.0001 pearson tests fisher df asquare exact test prob alternative hypothesis left abortion="Y)" is greater for alcohol use none than b chisquare>ChiSq Right <.0001 prob abortion="Y)" is greater for alcohol use than a none likelihood ratio different across pearson :.0001 odds fisher exact test alternative hypothesis lower upper left abortion-y c right heous relative risk description drinks p plot mosaic spontaneous in freq contingency table count n total row tests df asquare e chisquare>ChiSq Tests Likelihood Ratio 71.369 <.0001 asquare pearson fisher chisquare probechisq likelihood ratio exact test prob alternative hypothesis left abortion="Y)" is greater for alcohol use none than d right a different across e richt odds lower upper relative risk description drinks k p analysis of spontaneous by mosaic plot y n te.4 freq: freq contingency table count total row b jdrinks tests df rsquare>Chisq Likelihood Ratio 135.874