Homework #1: Osmolarity/Tonicity Problem: A patient has the following volumes of distribution: deuterium oxide: 40 liters inulin: 13 liters Evans blue: 2.8 liters Her plasma Osmolarity is 285mOsM. 1. How much solute (osmoles) exists in each of the above compartments? Using the data above as the initial conditions in each case, determine the effects of the following procedures on the water and solute in the ECF and ICF after equilibrium has occurred. You should be able to give the numerical values for volume and osmolarity of the ECF and ICF. Briefly explain your rationale for solving each problem. (Treat each solution below as a separate problem; do not make them additive.) 2. Patient ingests 1 L of water, which is absorbed totally from the digestive tract. 3. Patient ingests 0.18 moles of NaCl, all of which is absorbed into the body. Use dissociation constant of 2 for NaCl in all problems. 4. Patient receives an intravenous infusion of 2 L of 0.9% NaCl solution. 5. Patient ingests 1 L of water containing 0.3 moles of urea, all of which is absorbed. Instructions 1. Use this template and write your answers in neatly. 2. Rounding as instructed or your answers may not be correct. For volume, round to 0.1 L For solute, round to 0.001 osmoles For osmolarity, use mOsm (e.g., 300 mOsM) 3. Explanations should be brief and should largely address rationale for distribution of solute and water. 1. (10pts) Total ECF ICF Plasma Vol L Sol osmol mOsM 2. (20pts) Explanation: Total ECF ICF Vol L Sol osmol mOsM 3. (20pts) Total ECF ICF Explanation: Vol L Sol osmol mOsM 4. (20pts) Total ECF ICF Explanation: Vol L Sol osmol mOsM 5. (30pts) Work in 2 steps. Stepl: Add water only, not penetrating particles yet. Remember to explain why? Total ECF ICF Explanation: Vol L Sol osmol mOsM Step2: Add penetrating particles and calculate new osmolarity. Total ECF ICF Vol L Sol osmol mOsM