However, if you're in a hurry and you can manually interrupt your program under the debugger while it's being subjectively slow, there's a simple way to find performance problems.

Just halt it several times, and each time look at the call stack. If there is some code that is wasting some percentage of the time, 20% or 50% or whatever, that is the probability that you will catch it in the act on each sample. So, that is roughly the percentage of samples on which you will see it. There is no educated guesswork required. If you do have a guess as to what the problem is, this will prove or disprove it.

You may have multiple performance problems of different sizes. If you clean out any one of them, the remaining ones will take a larger percentage, and be easier to spot, on subsequent passes. This magnification effect, when compounded over multiple problems, can lead to truly massive speedup factors.

Caveat: Programmers tend to be skeptical of this technique unless they've used it themselves. They will say that profilers give you this information, but that is only true if they sample the entire call stack, and then let you examine a random set of samples. (The summaries are where the insight is lost.) Call graphs don't give you the same information, because

They don't summarize at the instruction level, and

They give confusing summaries in the presence of recursion.

They will also say it only works on toy programs, when actually it works on any program, and it seems to work better on bigger programs, because they tend to have more problems to find. They will say it sometimes finds things that aren't problems, but that is only true if you see something once. If you see a problem on more than one sample, it is real.