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Biopharmaceutics and Pharmacokinetics PHCL 4160/6160 Homework Assignment \#5 Two-Compartment Model Zero-Order Absorption Homework Assignment Due: by start of class on Tuesday, February 21, 2023 Assignment worth 60 points ( 5 points per variable) Styrene is a chemical monomer (precursor to a polymer) used in the common industrial production of polystyrene products such as Styrofoam. Styrene monomer is a volatile chemical which can be toxic when inhaled in large quantities. The following blood styrene measurements were made in human volunteers exposed to 80ppm styrene monomer for 6hr. Analyze the measurements for the post-exposure period ( t6 hr) and perform the necessary calculations to determine: B1,B2, hybrid rate constants (4,2), t t/2ode, t1/2,lim, model rate constants (k10,k12,k11), central Styrene is a chemical monemer (orecurvor to a polymer) used in the common industrial precuction of polyphrene products wuch as 5tyrefoam. Styeene moremer is a volatile chemical which can be toxic when inhaled in large quantities. The lollowing blood styrene measurements were made in truman volunteens exposed ta 80 ppen styenene monomer for 6 he. Aralyae the measucements for the pous expoture peried (ar ehif) and perform the necessary calculations to determinei campietment volume NiL strady-state volame (Nul, and clearance (Ci) Biopharmaceutics and Pharmacokinetics PHCL 4160/6160 Homework Assignment \#5 Two-Compartment Model Zero-Order Absorption Homework Assignment Due: by start of class on Tuesday, February 21, 2023 Assignment worth 60 points ( 5 points per variable) Styrene is a chemical monomer (precursor to a polymer) used in the common industrial production of polystyrene products such as Styrofoam. Styrene monomer is a volatile chemical which can be toxic when inhaled in large quantities. The following blood styrene measurements were made in human volunteers exposed to 80ppm styrene monomer for 6hr. Analyze the measurements for the post-exposure period ( t6 hr) and perform the necessary calculations to determine: B1,B2, hybrid rate constants (4,2), t t/2ode, t1/2,lim, model rate constants (k10,k12,k11), central Styrene is a chemical monemer (orecurvor to a polymer) used in the common industrial precuction of polyphrene products wuch as 5tyrefoam. Styeene moremer is a volatile chemical which can be toxic when inhaled in large quantities. The lollowing blood styrene measurements were made in truman volunteens exposed ta 80 ppen styenene monomer for 6 he. Aralyae the measucements for the pous expoture peried (ar ehif) and perform the necessary calculations to determinei campietment volume NiL strady-state volame (Nul, and clearance (Ci)