In a first order elimination process, if the concentration of drug in plasma at time 2h is 8 mg/mL, what will be the concentration at 5h if the clearance and volume of distribution are 5 L/h and 10 L respectively?

b)If the clearance of the above drug changes to 20 L/h, due to administration with Omeprazole, what is the apparent volume of distribution of this drug?

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