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In a round bottom flask with a mixture that is being heated in hot water, why must a cork be loose at the neck of

In a round bottom flask with a mixture that is being heated in hot water, why must a cork be loose at the neck of the flask? Specifically in the reaction of 2 NH3+ CH3CH2CH2CH2CH(Br)CO2H NH4 + CH3CH2CH2CH2CH(NH3+)CO2- (norleucine) And why should its crystallization happen at room temperature at first rather than using an ice bath?

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