Answered step by step
Verified Expert Solution
Question
1 Approved Answer
In contrast to their addition to esters, Grignard reagents add to dimethyl formamide (DMF) once. Why is this? Propose a mechanism for all three steps
In contrast to their addition to esters, Grignard reagents add to dimethyl formamide (DMF) once. Why is this? Propose a mechanism for all three steps for the reaction shown below. The 1-carbon Homologation of alkyl or aryl bromides using Grignards and DMF. 1. Mg,Et2O RX 2. DMF X=Cl,Br,I 3. HCl,H2O The addition of a Grignard to DMF results in the generation of the corresponding aldehyde. When is the aldehyde formed, before or after acidic workup? What would happen (if anything) if you generated the aldehyde before workup
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started