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In order to study the drug release from a new manufacture cylindrical drug capsule, the drug capsule l ) tested in a S - A

In order to study the drug release from a new manufacture cylindrical drug capsule, the drug capsule l) tested in a S- A small reservoir of water (component B) was kept a 37C and the capsule was inserted into the reservoir. The drug capsule has a diameter of 0.65mm and height of 6.9mm. Pure solid drug A is loaded into the drug capsule to a depth of 4.3mm. The drug (component A) dissolves into the water (component B) inside the reservoir.
You may assume that the diffusion process is a p2 seudo-steady state. dilute system, and one-dimensional in the 2-direction. The water reservoir aets as apintinite sing for the drug so that CA2=0, and the drug does not chemically react inside the water.
The density of the Drug (A) i 50.9gcm3 the molecular weight of the drug is 150gmol, The maximum solubility of drug A in water is CAS=2.710-3molcm3, Diffusion coefficient, DAB of the drug (s 4.510)cm2s
Simplify the differential equation of mass transfer?
Simplify the flux equation of mass transfer?
State the assumption you have used in part 1&2?
Develop a simple model, in final integrated form to predict the flux of the drug from the drug .. capsule?
Calculate the Gotal drug belease rate from the capsul Wmols?
Calculate thd fimo it will take the entirc drug to be released? Water, C
grad*NA+delcAdelt-RA=0,NA=-cDABgradyA+yA(NA+NB)
delcAdelt+[delNA,xdelx+delNA,ydely+delNA,zdelz]=RA Rectangular coordinates
delcAdelt+[1rdeldelr(rNA,r)+1rdelNA,del+delNA,zdelz]=RA Cylindrical coordinates
delcAdelt+[1r2deldelr(r2NA,r)+1rsindeldel(NA,sin)+1rsindelNA,del]=RA Spherical coordinates
Rectangular coordinates
Spherical Cylindrical coordinates
grad*NA+delcAdelt-RA=0,NA=-cDABgradyA+yA(NA+NB)
delcAdelt+[delNA,xdelx+delNA,ydely+delNA,zdelz]=RA Rectangular coordinates
delcAdelt+[1rdeldelr(rNA,r)+1rdelNA,del+delNA,zdelz]=RA Cylindrical coordinates
delcAdelt+[1r2deldelr(r2NA,r)+1rsindeldel(NA,sin)+1rsindelNA,del]=RA Spherical coordinates
coordinates
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