Question: In step (i), dimethylamine (Me2NH) first combines with formaldehyde (CH2O) to form an imine (Me2N=CH2); this Mannich electrophile then reacts with 5 in an SEAr

I, Me,NH.HCI, CH;0 O C, 3 hours H. HS(CH),NH2, conc. HC OC,

In step (i), dimethylamine (Me2NH) first combines with formaldehyde (CH2O) to form an imine (Me2N=CH2); this ‘Mannich electrophile’ then reacts with 5 in an SEAr reaction. Propose a mechanism for step (i). (5 marks)

I, Me,NH.HCI, CH;0 O C, 3 hours H. HS(CH),NH2, conc. HC OC, 18 hours 5 OH 6 OH NH2

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