Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

In the alkylation of carbonyls, a base is used to generate the enolate. Then, alkylation with an electrophile can occur. Depending on the conditions, two

image text in transcribed

In the alkylation of carbonyls, a base is used to generate the enolate. Then, alkylation with an electrophile can occur. Depending on the conditions, two different enolates (kinetic or thermodynamic) can form, resulting in different products being formed (A or B), as shown in the reaction below. Two bases are provided, CH3CH2ONa and LDA, that result in different products. 1) Draw a mechanism for the reaction with CH3CH3ONa as the base (choosing the correct major product) and discuss each step, including a discussion as to whether the kinetic or thermodynamic enolate is formed. 2) Then,explain why LDA provides the other product as the major product. 1. Base 2. A

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image_2

Step: 3

blur-text-image_3

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Organic Chemistry

Authors: Joseph M. Hornback

2nd Edition

9781133384847, 9780199270293, 534389511, 1133384846, 978-0534389512

More Books

Students also viewed these Chemistry questions