In the field of analytical chemistry, which statement accurately describes the challenges or limitations associated with Mass Spectrometry (MS) as an analytical technique? A) Mass spectrometry is unable to differentiate between isotopes of the same element, limiting its usefulness in isotope ratio studies. B) One of the major challenges in mass spectrometry is the inability to provide structural information about the analyte, as it only measures the mass-to-charge ratio of ions. C) A key limitation of mass spectrometry is its inability to analyze high molecular weight compounds, making it unsuitable for the study of large biomolecules like proteins. D) In mass spectrometry, one of the significant challenges is the potential for fragmentation of the analyte, which can complicate the interpretation of the mass spectrum, especially in the analysis of complex mixtures.