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Instructions: Trial A (simple randomization) Flip a coin and assign Treatment A if heads and Treatment B if tails. Trial B (blocked randomization) Use Table
Instructions:
- Trial A (simple randomization)
- Flip a coin and assign Treatment A if heads and Treatment B if tails.
- Trial B (blocked randomization)
- Use Table 10-6 (attached).
- Start in column 41, row 17, moving left to right and top to bottom.
- Using a block size of 4, if random number is:
-1 assign AABB
-2 assign ABAB
-3 assign ABBA
-4 assign BABA
-5 assign BBAA
-6 assign BAAB
-skip if 0, 7-9
- Trial C (stratified randomization)
- Use Table 10-6 (attached).
- For clinic 1 start in column 35, row 6, moving left to right and top to bottom.
- For clinic 2 start in column 6, row 10, moving left to right and top to bottom.
- Use a variable block size alternating between block size of 4 and block size of 2.
- When using a block size of 4, if random number is:
-1 assign AABB
-2 assign ABAB
-3 assign ABBA
-4 assign BABA
-5 assign BBAA
-6 assign BAAB
-skip if 0, 7-9
- When using a block size of 2, if random number is even assign AB and if random number is odd assign BA.
Questions:
- Why do or why don't the treatment groups deviate from the allocation ratio in each trial?
- What is the minimum block size for a trial of 3 treatment groups stratified by 3 clinics, and an allocation ratio of 1:1:2?
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