Is the difference between the three groups statistically significant? How do you know? The p-value associated with the F-statistic is not less than .05. Thus, the means are significantly different. The p-value associated with the F-statistic is less than .05. Thus, the means are significantly different. The p-value associated with the F-statistic is less than .05. Thus, the means are not significantly different. The p-value associated with the F-statistic is not less than .05. Thus, the means are not significantly different