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It is typically very difficult to do a substitution reaction on an aromatic ring when the leaving group is flanked by two other bulky substituents.

It is typically very difficult to do a substitution reaction on an aromatic ring when the leaving group is flanked by two other bulky substituents. Moreover, in Section 22.3, we found that nucleophilic aromatic substitution requires strongly electron-withdrawing groups on the benzene ring. However, Pd-catalyzed coupling allows entry into such products. As examples, write the products of the following reactions and state which coupling reaction is being utilized.

 

OTF n-BugSn Pd(0), PPh excess Ph Pd(PPhg) 4, Cul, NEts

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