It was hypothesized that the amount of aspirin in a drug is associated with the reduction of fever during flu. Drug A is 100% aspirin, drug B is 50% aspirin and 50% other compounds; drug C is 25% aspirin and 75% other compounds. The drugs are prescribed to children aged 5 - 14 entering the outpatient ward of a hospital complaining of the flu with fever of 100 degree F to 100.9 degree F. The drugs are assigned in time sequence order, i.e. the first patient gets drug A, the second drug B, third drug C, the fourth drug A and so forth until there is a set of 15 patients. The reduction in fever after four hours is noted and the results are given below.

Drug

Reduction in fever

A

2.0

2.6

2.1

1.6

1.3

B

0.5

1.2

0.3

1.2

-0.4

C

1.1

-1.0

-0.2

0.2

0.3

Carry out a significance test at 5% level of significance. You are given that the reduction in fever does follow normal distribution. Perform Bonferroni's pairwise comparisons if necessary.