Lab 4 Synthesis of Aspirin Name Pre-Lab Exercise: Please complete the following activities before you come to the lab. (10 pts) Introduction The popular NSAID (non-steroidal anti-inflammatory drug) pain reliever aspirin has the common chemical name of acetylsalicylic acid. Although its most common use is as an anti-inflammatory', aspirin is also commonly used as a therapy for cardiovascular disease (CVD)'. The chemical structure of aspirin is shown below. Originally registered by the Bayer Chemical Company in 1899 , aspirin became a stamped pill for human use in 1904 . Today, annual production of aspirin is around 40,000 tons, and in the United States alone, over 50 million people regularly take between 10 and 20 billion aspirin pills for the prevention of CVD'. 1. Answer true or false: (1 pt each) a. Salicylic acid is aspirin b. Aspirin contains a cyclohexane functional group c. An Erlenmeyer flask looks exactly like a beaker d. Aspirin contains an ether functional group 2. List the personal protective equipment that should be used whilst performing this experiment? ( 2 pts) 3. Salicylic acid is a solid - the sample mass can be easily converted into moles (using the molecular weight) when calculating the theoretical yield of aspirin product. Acetic anhydride on the other hand, is a liquid. What other characteristic of acetic anhydride needs to be used in order to calculate moles of acetic anhydride? ( 2 pts) 4. If you get either acetic anhydride or phosphoric acid on your skin, what should you do? ( 2 pts) 1. Fuster, V., Sweeney, J. 'Aspirin: A Historical and Contemporary Therapeutic Overview' Circulation, 2011, 123, p.768 - 778