managerial accounting Transferring the leadership and ownership of project management from professional project managers to the engineering division has allowed further entrenching of the organization's goal of increasing project management maturity and has produced positive results. Senior-level managers in the organization expect 100 percent compliance with the project management tools and methodologies developed by the project management office and approved by the governance board. They approached the changes as sustained continuous improvement and took the time to listen to comments and criticism from the people in the framework, which resulted in less overall resistance than was expected. Another method used by the Electrical/Electronic Systems Engineering department to counter resistance was to design the project management office framework around stakeholder participation. All organization personnel can participate in the project management office tools and methodology discussions at the management level, as well as the project management office working level meetings. This level of participation in the organization helps build the best practice process.

131 If a female patient with multiple sclerosis wants to become pregnant, what are the risks, family planning advice and treatment, etc? What is the best advice to give to her?

132 Is there a role for methotrexate and azathioprine in the treatment of remitting-relapsing multiple sclerosis?

133 Do steroids have a role in preventing or ameliorating the relapses in relapsing-remitting multiple sclerosis?

134 Has cyclophosphamide a role in decreasing the rate and number of relapses in relapsing-remitting multiple sclerosis?

135 Is there evidence of the efficacy of cyclic pulse cyclophosphamide therapy in the treatment of relapsing-remitting multiple sclerosis?

136 Glatiramer acetate and interferon-beta are recommended by some people for the treatment of multiple sclerosis. Which drug should I use for a patient with a 2-year history of relapsing-remitting MS.

137 1. Most neurological books available to me say that high-dose IV dexamethasone can be used in acute relapses of multiple sclerosis (MS). What is the recommended dosage and regimen for this drug? 2. I understand that depot preparations of betamethasone (Depofos) can also be used in acute relapses of MS, as well as treatment for idiopathic Bell's palsy. If so, can you tell me the recommended dosage and regimen for this drug?

138 What are the most common causes of chronic meningitis and what investigations must be done?

139 What is Hib meningitis?

140 How often is tuberculosis a cause of chronic meningitis in comparison to other causes?