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Matlab programming problem 3. Control of drug release in dissolution through pill coating - non-steady-state dissolution of solid in solution: The pill contains pure drug

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3. Control of drug release in dissolution through pill coating - non-steady-state dissolution of solid in solution: The pill contains pure drug D in its core, with the external layer surrounded by the coating A to control drug release. Inside the stomach the outer coating and the drug dissolve at different rates. Set Cas- coating concentration in stomach (mg/cm Cos drug concentration in stomach (mg/ cm) CDB drug concentration in body (blood) (mg/kg) (not used in this exam) Now suppose the pill has sizes: DA 5 mm, DD 3 mm In which, Ds is the diameter of the coating A of the pi and Do the diameter of pure drug D of the pill. Other data related to this process: Dose in the kernel of the pill 20 mg, (not used in this exam Total density of inner and outer layers p 1414.7 mg/cm Solubility of coating in stomach S1.0 mg/em Solubility of lining drug in stomach -Sp-0.4 mg/cm3 Volume of stomach fluid = V= 1200 cm3 3. Control of drug release in dissolution through pill coating - non-steady-state dissolution of solid in solution: The pill contains pure drug D in its core, with the external layer surrounded by the coating A to control drug release. Inside the stomach the outer coating and the drug dissolve at different rates. Set Cas- coating concentration in stomach (mg/cm Cos drug concentration in stomach (mg/ cm) CDB drug concentration in body (blood) (mg/kg) (not used in this exam) Now suppose the pill has sizes: DA 5 mm, DD 3 mm In which, Ds is the diameter of the coating A of the pi and Do the diameter of pure drug D of the pill. Other data related to this process: Dose in the kernel of the pill 20 mg, (not used in this exam Total density of inner and outer layers p 1414.7 mg/cm Solubility of coating in stomach S1.0 mg/em Solubility of lining drug in stomach -Sp-0.4 mg/cm3 Volume of stomach fluid = V= 1200 cm3

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