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Methods II Clinical chemistry, Feb 2 problem set 1. A diabetic person comes to the emergency room presenting with tachycardia (elevated heart rate), dizziness, and

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Methods II Clinical chemistry, Feb 2 problem set 1. A diabetic person comes to the emergency room presenting with tachycardia (elevated heart rate), dizziness, and sweating. The patient is asked if they are on any medications, and they state they have a prescription for Novolog. They also state that they are going to a fancy restaurant later that evening and haven't eaten anything, so they don't spoil their appetite. a. Hospital lab tests find the patient is hypoglycemic but has high insulin. Why does this not make sense? b. The patient's sample is sent out to a core lab to confirm the results. However, the results show hypoglycemia with low insulin. What additional test(s) would you suggest to explain the discrepancy between the hospital and core lab results? Explain your answer. 2. Below is a table describing the onset, peak, and duration of human insulin and synthetic insulins. Table of Insulin Action The graph below shows the onset, peak, and duration for each type of insulin in the table above. Use the table above to label each trace in the graph below with the appropriate type of insulin. Activity Profiles of Different Types of Insulin 3. China white is the street name for 3-methyl-fentanyl, a short-acting synthetic opioid agonist estimated to have 10,000 times the potency of heroin at -opioid receptors. Pharmaceutical fentanyl has a potency of 100 times that of heroin, while the commonly used opioid analgesic morphine is approximately 5 times less potent than heroin. All four drugs are equally efficacious with respect to the effects produced by their activation of opioid receptors. If the ED50 of heroin at -opioid receptors is 10mg/kg. using the axes below, draw dose-response curves to show the expected relative relationships between heroin, fentanyl, morphine and China White (3-methyl fentanyl), and indicate their respective ED 50 's and show their location in the figure. Drug dose

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