Misclassification Scenario 1 Women were asked to recall their HRT exposure experience recall is almost never perfect Twenty percent of women who actually had taken HRT said that they hadn't, whereas ten percent of women who actually had not taken HRT said that they had This occurred regardless of disease status CHD CHD Total HRT 200 5110 5310 HRT 170 5259 5429 Total 370 10369 10739 Use the table below to calculate the 2x2 table with misclassification Final table with misclassification CHD CHD Total HRT HRT Total What are the risk ratio and risk difference in the misclassified table Calculate and interpret Compare the risk ratio in question 3 to the true risk ratio in question 1 How did misclassification of the exposure independent of disease status (non differential misclassification of exposure) affect the estimates in the study Misclassification Scenario 2 Twenty percent of the nonusers with CHD were categorized as users Everyone else was classified accurately according to the TRUTH table above Is this an example of misclassification of exposure or disease Fill in the table below with the misclassified 2x2 table CHD CHD Total HRT HRT Total Table with misclassification CHD CHD Total HRT HRT Total What are the risk ratio and risk difference in the misclassified table Calculate and interpret How did this misclassification affect the estimates in the study

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Misclassification Scenario 1: Women were asked to recall their HRT exposure experience; recall is almost never perfect. Twenty percent of women who actually had taken

Misclassification Scenario 1:

Women were asked to recall their HRT exposure experience; recall is almost never perfect. Twenty percent of women who actually had taken HRT said that they hadn't, whereas ten percent of women who actually had not taken HRT said that they had. This occurred regardless of disease status.

CHD+

CHD-

Total

HRT+

200

5110

5310

HRT-

170

5259

5429

Total

370

10369

10739

Use the table below to calculate the 2x2 table with misclassification.

Final table with misclassification:

CHD+

CHD-

Total

HRT+

HRT-

Total

What are the risk ratio and risk difference in the misclassified table? Calculate and interpret.

Compare the risk ratio in question 3 to the true risk ratio in question 1. How did misclassification of the exposure independent of disease status (non-differential misclassification of exposure) affect the estimates in the study?

Misclassification Scenario 2:

Twenty percent of the nonusers with CHD were categorized as users. Everyone else was classified accurately according to the TRUTH table above.