Multiple myeloma plasma cancer is characterized be increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patients own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.

Before - 158, 189, 202, 353, 416, 426, 441

After - 284, 214, 101, 227, 290, 176, 290

Questions.

1 - What is the null hypothesis to determine if the bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?