Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

Need help specifically with the stereochemistry. 3. Insulin is a multipeptide hormone that is released in response to high blood glucose levels thereby regulating the

Need help specifically with the stereochemistry. image text in transcribed

3. Insulin is a multipeptide hormone that is released in response to high blood glucose levels thereby regulating the metabolism of carbohydrates, fats, and proteins. Shown below a ribbon representation of the 3D structure as well as a pictorial representation of the primary sequence (PDB = 1trz). Answer the following questions about this peptide. [30 pts.] a) Draw the chemical structure of the last eight amino acids in the B chain in the correct protonation state. \{Note: Make sure not to ignore stereochemistry.\} b) Of the amino acids you drew in part a, identify the most acidic side chain and calculate the protonation state (\% protonated, \% deprotonated) at a physiologically relevant pH. c) Of the amino acids you drew in part a, identify the most basic side chain and calculate the protonation state (\% protonated, \% deprotonated) at a physiologically relevant pH

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Organic Chemistry

Authors: John E. McMurry

2nd Edition

495391441, 978-0495391449

More Books

Students also viewed these Chemistry questions

Question

Compute the derivative of f(x)cos(-4/5x)

Answered: 1 week ago

Question

Discuss the process involved in selection.

Answered: 1 week ago

Question

Differentiate tan(7x+9x-2.5)

Answered: 1 week ago

Question

Explain the sources of recruitment.

Answered: 1 week ago