Need help to solve homework excercise from section 6.6 of triola stats

The probability of flu symptoms for a person not receiving any treatment is 0.047. In a clinical trial of a common drug used to lower cholesterol, 45 of 897 people treated experienced flu symptoms. Assuming the drug has no effect on the likelihood of flu symptoms, estimate the probability that at least 45 people experience flu symptoms. What do these results suggest about flu symptoms as an adverse reaction to the drug?

(a)P(X45)=

(b) What does the result from part(a) suggest?