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Omeprazole is administered orally as a galenic formulation to protect it from being activated during its journey through the acidic contents of the stomach. Once
Omeprazole is administered orally as a galenic formulation
to protect it from being activated during its journey through
the acidic contents of the stomach. Once it is released in the
intestines, it is absorbed into the blood supply and carried
to the parietal cells where it crosses the cell membrane into
the canaliculi and is activated. As the canaliculi lead directly
into the lumen of the stomach, why is omeprazole not orally
administered directly to the stomach?
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