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Passage 10 (Questions 1-6) Figure I below is a pedigree of three generations showing the occurrence of two genetically-transmitted diseases, Disease 1 and Disease 2,
Passage 10 (Questions 1-6) Figure I below is a pedigree of three generations showing the occurrence of two genetically-transmitted diseases, Disease 1 and Disease 2, which are rare and unlinked. Phenotypes of affected individuals are shown, Circles represent females, and squares represent males. Assume that individuals not blood related to Individuals I.a and I.b ("in-laws") do not possess either disease-producing allele. Generation O O O m III P w O Key: Disease I - Disease 2 - Both diseases Figure 1 Pedigree 1. Which one of the following statements is true concerning Individual I.a? A. He is homozygous for Disease 1, and the allele for this disease is autosomal recessive. B. He is heterozygous for Disease I, and the allele for this disease is X-linked recessive. C. He is heterozygous for Disease 1, and the allele for this disease is dominant. D. None of the above is necessarily true. 2. The genotype of Individual 1.b for Disease 2 is: A. homozygous recessive. B. heterozygous. C. homozygous dominant. D. Not enough information to determine 3. If Individual III.r marries a normal man with a homozygous wild-type genotype. what is the probability that their son would have Disease 2? A. 0 B. 1/4 C. 1/2 D. 3/4 4. If Individual III.v marries a normal man, what is the probability that their son would have both diseases? A. 0 B. 1/16 C. 1/8 D. 1/4 5. What is the probability that offspring produced by a mating between Individuals III.j and III.m would be afflicted with either Disease 1 or Disease 27 A. 1/4 B. 1/2 C. 3/4 D
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