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Pharmacokinetic models are used to describe the distribution of a drug molecule throughout the body flowing into and out of organs. In this example we
Pharmacokinetic models are used to describe the distribution of a drug molecule throughout the body flowing into and out of organs. In this example we will look at the decomposition of a drug molecule as it flows into an organ where it undergoes a chemical reaction. The flow rate of blood into and out of the organ is given by The drug enters at a concentration and goes through a deactivation reaction, leaving at a concentration The deactivation reaction rate is given by the following
expression: We will assume that the organ is well mixed and the concentration of drug throughout the organ is The organ has a volume of
A Is the process continuous, batch, or semibatch? Is it transient or at steady state? Why?
B Draw and label a block flow diagram of the process.
C What would you expect to be if the reaction rate constant was small,
What would you to be if the reaction rate constant was large,
D Using a differential material balance, identify the terms for the rate accumulation, input, output, consumption, and generation for the drug some of these maybe Solve this equation to give a function that calculates based on the other values in the problem.
E Using the equation in part D show that your predictions from C are correct.
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