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Pharmacokinetic models are used to describe the distribution of a drug molecule throughout the body flowing into and out of organs. In this example we

Pharmacokinetic models are used to describe the distribution of a drug molecule throughout the body flowing into and out of organs. In this example we will look at the decomposition of a drug molecule as it flows into an organ where it undergoes a chemical reaction. The flow rate of blood into and out of the organ is given by v(mLmin). The drug enters at a concentration CD,o(molDmL) and goes through a deactivation reaction, leaving at a concentration CD(molDmL). The deactivation reaction rate is given by the following
expression: r(mDlDmin)=kVCD. We will assume that the organ is well mixed and the concentration of drug throughout the organ is CD. The organ has a volume of V(mL).
A) Is the process continuous, batch, or semi-batch? Is it transient or at steady state? Why?
B) Draw and label a block flow diagram of the process.
C) What would you expect CD to be if the reaction rate constant was small, k0?
What would you CD to be if the reaction rate constant was large, k?
D) Using a differential material balance, identify the terms for the rate accumulation, input, output, consumption, and generation for the drug (some of these maybe 0). Solve this equation to give a function that calculates CD based on the other values in the problem.
E) Using the equation in part D), show that your predictions from C) are correct.
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