Pharmacokinetics

Please solve all problems with a brief description. Answers are given

Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC 0of efalizumab following a single 1 mg/kg i.v dose is 18 (mg.days)/L while the AUC 0after a single 10 mg/kg i.v dose is 460 (mg.days)/L. The clearance of Efalizumab in a 70 kg person after the 1 mg.kg i.v. dose is 3.9 L/day

> True

X False

Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC 0of efalizumab following a single 1 mg/kg i.v dose is 18 (mg.days)/L while the AUC 0after a single 10 mg/kg i.v dose is 460 (mg.days)/L. Antibodies like Efalizumab are proteins and similar to large protein therapeutics like human growth hormone they have very short half-lifes.

X True

> False

The average urinary excretion rate of the drug in the 0 - 4 hour interval is:

A: 10.4 mg/hrs

> B: 24.3 mg/hrs

X C: 39.5 mg/hrs

X D: 97 mg/hrs

X E: None of the above

The urinary excretion rate constant of the drug is:

X A: 0.105 1/hrs

X B: 0.135 1/hrs

X C: 0.183 1/hrs

X D: 0.212 1/hrs

> E: None of the above

The cumulative amount of drug excreted into the urine at time infinity (D u,is 175 mg while the AUC 0 of the drug is 76 (mg x hr)/L. The renal clearance of the drug is:

X A: 1.6 L/hr

> B: 2.3 L/hr

X C: 3.7 L/hr

X D: 4.5 L/hr

X E: None of the above

Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC Oof efalizumab following a single 1 mg/kg iv dose is 18 (mg.daysML while the AUC Oafter a single 10 mg/kg iv dose is 460 (mg.days)L. The clearance of Efalizumab in a 70 kg person after the 1 mg kg i.v. dose is 3.9 L/day > True X False Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC Oof efalizumab following a single 1 mg/kg iv dose is 18 (mg.days)/L while the AUC Oafter a single 10 mg/kg i. dose is 460 (mg.days)L. Antibodies like Efalizumab are proteins and similar to large protein therapeutics like human growth hormone they have very short half-lifes. X True > False The average urinary excretion rate of the drug in the 0 - 4 hour interval is: A: 10.4 mg/hrs >B: 24.3 mg/hrs X C: 39.5 mg/hrs XD: 97 mg/hrs XE: None of the above The urinary excretion rate constant of the drug is: XA: 0.1051/hrs XB:0.135 1/hrs X C: 0.183 1/hrs XD: 0.212 1/hrs > E: None of the above The cumulative amount of drug excreted into the urine at time infinity (Duis 175 mg while the AUC 0 of the drug is 76 (mg x hryL. The renal clearance of the drug is: XA: 1.6 Uhr >B: 2.3 L/hr X C: 3.7 L/hr X D: 4.5 L/hr XE: None of the above Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC Oof efalizumab following a single 1 mg/kg iv dose is 18 (mg.days) while the AUC Dafter a single 10 mg/kg iv dose is 460 (mg days)L. The clearance of Efalizumab in a 70 kg person after the 1 mg kg iv. dose is 3.9 L/day > True X False Efalizumab is a monoclonal antibody approved for use in psoriasis. The AUC of efalizumab following a single 1 mg/kg iv dose is 18 (mg.days) while the AUC Oafter a single 10 mg/kg iv dose is 460 (mg.days L. Antibodies like Efalizumab are proteins and similar to large protein therapeutics like human growth hormone they have very short half-lifes X True > False The average urinary excretion rate of the drug in the 0 - 4 hour interval is: A: 10.4 mg/hrs >B: 24.3 mg/hrs XC: 39.5 mg/hrs XD: 97 mg/hrs XE: None of the above The urinary excretion rate constant of the drug is: XA: 0.1051/hrs XB:0.135 1/hrs XC: 0.183 1/hrs XD: 0.212 1/hrs >E: None of the above The cumulative amount of drug excreted into the urine at time infinity (Duis 175 mg while the AUC 0 of the drug is 76 (mg x hryl. The renal clearance of the drug is: XA: 1.6 L/hr >B: 2.3 L/hr X C: 3.7 L/hr X D: 4.5 L/hr XE: None of the above