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Please answer all parts! The structure of metronidazole, an antibiotic that is on the World Health Organisation's list of essential medicines, is shown below. This
Please answer all parts!
The structure of metronidazole, an antibiotic that is on the World Health Organisation's list of essential medicines, is shown below. This compound is an example of a synthetic imidazole derivative that has a biological application. Show how a knowledge of the chemistry of pyridine and pyrrole can be used to predict the chemistry of imidazole. You should discuss: (i) Basicity (the pKa of the conjugate acid of imidazole is 6.9, of pyridine is 5.2 and of pyrrole is 3.8 ). (ii) Acidity (the pKa of imidazole is 14 and of pyrrole is 17 ). (iii) Electrophilic aromatic substitutionStep by Step Solution
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