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Please show the mechanism for the synthesis above. OTBS OTBS OTBS c) NiCl,-6H20 NABH4 a) [Pd], dppf, 14, OTBS PhCI, 130 C b) TBSCI 85%
Please show the mechanism for the synthesis above.
OTBS OTBS OTBS c) NiCl,-6H20 NABH4 a) [Pd], dppf, 14, OTBS PhCI, 130 C b) TBSCI 85% [20 g scale] TBSO 69% o,H HO [8 g scale] (see Table S1) 13 16 O 15 17 [3 g scale] 33% 42% 9 OTBS d) LHMDS PHNTF2 e) [Pd), 10 , H 68% (2 steps) [gram scale] 18 TBSO OTBS OTBS OTBS c) NiCl,-6H20 NABH4 a) [Pd], dppf, 14, OTBS PhCI, 130 C b) TBSCI 85% [20 g scale] TBSO 69% o,H HO [8 g scale] (see Table S1) 13 16 O 15 17 [3 g scale] 33% 42% 9 OTBS d) LHMDS PHNTF2 e) [Pd), 10 , H 68% (2 steps) [gram scale] 18 TBSO OTBS OTBS OTBS c) NiCl,-6H20 NABH4 a) [Pd], dppf, 14, OTBS PhCI, 130 C b) TBSCI 85% [20 g scale] TBSO 69% o,H HO [8 g scale] (see Table S1) 13 16 O 15 17 [3 g scale] 33% 42% 9 OTBS d) LHMDS PHNTF2 e) [Pd), 10 , H 68% (2 steps) [gram scale] 18 TBSO
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