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Prednisone is a corticosteroid used to treat many inflammatory diseases such as asthma, ulcerative colitis, arthritis, or acne. However, prolonged use of the drug can
Prednisone is a corticosteroid used to treat many inflammatory diseases such as asthma, ulcerative colitis, arthritis, or acne. However, prolonged use of the drug can cause patients to develop osteoporosis, low bone density. Recently a new drug, prednisolone has been developed that acts as anti-inflammatory with fewer side effects. To compare the drugs impact on bone density a study was done in which two groups of cats received equivalent doses of prednisone or prednisolone for an equivalent time period. At the end of the treatment period the bone density of both groups was measured. Each measurement represents an individual cat that was given either prednisone or prednisolone. Now the researchers want to use a t-test to see ifthe data show any differences between the treatments. Ho: There is no difference in the bone density between the two treatment groups HA: The prednisolone treatment groups bone density is different from the prednisone treatment group. Now you're going to determine the t-test probability Pm using the t-test formula in a spreadsheet. Copy the data over to Excel and perform all calculations in Excel. Note: We are looking for t-test ,orobaiEM'l'ftyr NOT the t-test value. The t-test probability is based on alpha = 0.05, where we reject the null if it's alpha is below. 1) Is this a one-tailed or two-tailed test? (you'll want this information for the formula that you will use) Also for the formula, assume unequal variance between treatment groups (specify type 3 t- test in your spreadsheet calculation) Click for the E_xperiment #3 data (Links to an external site.) 2) Copy and paste your calculated t-test probability to at least 6 decimal places. 3) Based on the t-test probability you would the null hypothesis? (reject, fail to reject) 4) Is it likely that the bone density of the prednisolone treatment group is greater than the prednisone treatment group
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