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Problem 2. Consider the following compartmental model of differentiation shown in the scheme below. This is an analytical problem requiring mathematical manipulations only, so show
Problem 2. Consider the following compartmental model of differentiation shown in the scheme below. This is an analytical problem requiring mathematical manipulations only, so show all math. Parameters: I is the input flux (constant), X is the cell concentration in compartment i, fis the fraction of self-renewal and u is the specific growth rate. (a) Derive the cell balance equation for compartment that describes the above process (b) Obtain an expression for X(t) if X{t=0) = Xo (c) What is the time constant, t, for this process? (d) Obtain an expression for the cell production rate, dx/dt as a function of time, t. Note this expression should include all constant parameters and initial cell concentration. (e) What happens if f>1/2? Iff=1/2
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