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Problem 5 Oxygen diffuses through the wall of drug containers and oxidizes many drugs rendering them inactive. It is the oxygen diffusion / reaction scenario
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Oxygen diffuses through the wall of drug containers and oxidizes many drugs rendering them inactive. It is the oxygen diffusionreaction scenario that limits the shelflife of many pharmaceutical products. To limit the oxidation of drugs, oxygen scavengers, like sodium bisulfite NaHSO are often added. The reaction to remove oxygen is:
Consider a liquid drug stored in a cylindrical polyethylene container. The container is high and has an inner diameter of The initial concentration of in the drug formulation is liter. How thick must the walls of the container be to ensure that of the remains after year? Neglect diffusion through the top and bottom of the container and assume that the reacts instantly with the so that the concentration in the drug is always The effective diffusivity of through polyethylene is and you may assume the partition coefficient is atm, and the process operates at steadystate. Enever Lewandowski and Taylor
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