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Q3. (60 points) 1) You are designing a new protein-based drug, whose function will be to act as an enzyme to break down the clot
Q3. (60 points) 1) You are designing a new protein-based drug, whose function will be to act as an enzyme to break down the clot in a blood vessel. The 20 common amino acids are at your disposal to make the protein. Your design is such that the protein must have 2 subunits (quaternary structure) as shown below. Two protein Enzyme subunits site that breaks the clot Edge where two subunits meet Enzyme site that breaks the clot a. What types of amino acids should you put along the edge of the two subunits that are touching each other, and why? (20 points) C. b. You want to make the interaction between the two subunits along the edge quite strong by introducing covalent cross-links. Which amino acid would you choose to place at that edge and why? (10 points) How would you prefer to deliver it, i) as an injectable liquid, or ii) an oral capsule. Explain why? (20 points)| d. Down the road, you discover that the protein you made (as shown above) works better if you were to 'decorate it on the surface of a lipid bilayer particle. How would you modify the protein to accomplish this goal? Give your reason clearly. (10 points)
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