Question 1

How do you calculate the plasma creatinine clearance value at the bedside, by body weight?

Question 2

Can you tell me whether administering low doses of dopamine to increase renal blood flow is today considered obsolete?

Question 3

Why does haemoglobinuria cause anuria?

Question 4

I am confused over the use of a 'high-protein diet' in the management

of nephrotic syndrome. You say it confers no advantage, but the Oxford

Handbook of Clinical Medicine advocates its use and Davidson's Principles

and Practice of Medicine says it is even dangerous as it could lead to renal

damage. Which one should I choose, assuming I see the question in

an MCQ?

Question 5

Is albumin infusion contraindicated in nephrotic syndrome? If not, then

what are the indications?

Question 6

Listed under the drug causes of nephrotic syndrome, it has been

stated that high doses of captopril can induce an immune-complexmediated membranous glomerulonephritis. If a patient with nephrotic

syndrome has hypertension, is it detrimental to give captopril as a

treatment for his hypertension? Could this exacerbate the patient's

nephrotic syndrome?

11 Renal disease

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Renal disease 11

103

Question 7

Please explain the pathophysiology of ascites in the nephrotic

syndrome?

Question 8

Does the nephritic syndrome cause hyperkalaemia? I don't seem

to be able to find a definitive answer in the textbooks that I have

consulted.

Question 9

You say that the investigation of first choice for urinary tract infections

(UTIs) in males or children, or recurrent UTIs in females, is intravenous

urography (IVU); in Oxford Handbook of Clinical Medicine it is ultrasound

(US). Which is best?

Question 10

1. Other than amoxicillin, what other orally administered drug is

recommended for the treatment of a urinary tract infection (UTI)

caused by enterococcus?

2. What is the recommended dosage for antibiotics in the prophylactic

treatment of recurrent UTI in pregnancy? Is amoxicillinclavulanic

acid safe to use during pregnancy?