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Question 2: Which of these parameters would you expect to be able to control in a real experiment? I need help with question 2 please

Question 2: Which of these parameters would you expect to be able to control in a real experiment?

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I need help with question 2 please

EXERCISES Because of license limitations, this simulation can only run from a limited set of computers. Most finish the prac within the hour or so. You can always access the program any time during the semester. You will have to log-on to your net-account and open NeuroSim: start / All Programs / Neuro Sim / Neuro Sim.exe (NeuroSim may be located somewhere else in All Programs") From within the first window, with credits etc, select 2: Goldman Ignore the Failed to update the system registry"-notice, just click OK. You will be using the Setup window only, so position it to your liking. Your screen should look something like shown below. BOX NeuroSim Goldman model - Default Eile Model Edit View Window Help BH % be a | | ?? Setup X Mem Pot -55.97 -100 mV +100 mV Na Eq 54.946 KE-7568 CI Eq -50.79 Graph Temp (C) Temp 20 Ion Concs (mm) [K] 20 400 - [Na] 440 50 560 75 Relative permeability Xage of normal PK) K Na CI 45 100 = 4 Chloride distribution Regulated Passive (CI) 560 1000.00 Done Familiarise yourself with the settings (hit any button you like - you can't cause any damage). The blue aquarium represents a tissue bath containing one cell (green) that is impaled by a recording electrode. You can set the temperature and external (bathing) concentrations of K-, Na-, and Cl-ions. In addition you can control the intracellular ion concentrations and set membrane permeabilities. Note that the permeabilities are relative to normal gk 2. Which of these parameters would you expect to be able to control in a 'real' experiment? The line at the top of the screen shows the equilibrium potential for each ionic species and the resultant membrane potential. Reset Temp to 20C and Chloride distribution Regulated'. Focus on one ion species only (potassium). Because the program does not accept zero-concentrations, enter ImM for [Na+] and [Cl-), both outside and inside (you can type-in 'l' or use the scrolling-arrows), also set the Relative 2 teaching2022/pha2pga/MemPot.ck

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