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QUESTIONS 1.As cells grow and regenerate, what mechanism does the body use to get rid of the continuously dying cells? And what kind of cells

QUESTIONS

1.As cells grow and regenerate, what mechanism does the body use to

get rid of the continuously dying cells? And what kind of cells can't be

replaced once dead?

2.I cannot find out why some of the autosomal dominant diseases have a

male or female preponderance, e.g. I have never seen a female Marfans. I

was attributing it to imprinting but on reading about imprinting in detail

it cannot be the case.

3.We have been told that some tumours in the colon are associated with

microsatellite instability. What does this mean?

4.I understand that microarrays are being used to define the molecular

abnormality and the prognosis in some patients with leukaemia. What

are microarrays?

5.Why do mitochondrial diseases cause a myopathy?

6.Why do successive generations of patients with some genetic disorders

present earlier and with progressively worse symptoms.

7.Does a normal serum uric acid level exclude the diagnosis of

Lesch-Nyhan syndrome?

8.How is retinoblastoma an autosomal dominant disease if the mutation of

both RB genes is required to express the disease?

9. Which Ancient Greek physician is known as 'the Father of Medicine' and still affirmed by all doctors in many countries today?

10. Extremely rare today, which disease, caused by a lack of ascorbic acid in the body, was the scourge of sailors up until the mid-18th century?

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